The role of O2•- radicals in DNA-metal complexes

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dc.contributor.author Anastassopoulou, JD en
dc.contributor.author Rakintzis, NTh en
dc.contributor.author Theophanides, TM en
dc.date.accessioned 2014-03-01T01:47:30Z
dc.date.available 2014-03-01T01:47:30Z
dc.date.issued 1998 en
dc.identifier.issn 00201693 en
dc.identifier.uri http://hdl.handle.net/123456789/25238
dc.relation.uri http://www.scopus.com/inward/record.url?eid=2-s2.0-0040598959&partnerID=40&md5=529083f8bbf93b28659e82148f810306 en
dc.subject DNA complexes en
dc.subject Platinum complexes en
dc.subject Superoxide radicals en
dc.title The role of O2•- radicals in DNA-metal complexes en
heal.type journalArticle en
heal.publicationDate 1998 en
heal.abstract The nucleotide 5′-guanosine monophosphate (5′-GMPNa2) was irradiated with γ-rays in aerated aqueous solutions in the absence as well as in the presence of cis-dichlorodiammineplatinum(II) (cis-DDP). The HPLC data of the radiolysis products suggest that O2• radicals reduce the Pt(II) complex formed to Pt(I) complex, which finally releases by disproportionation Pt metal, Pt(0). cis-DDP acts as a radiosensitizer and the irradiation in the presence of cis-DDP leads to the release of the base guanine. © 1998 Elsevier Science S.A. All rights reserved. en
heal.journalName Inorganica Chimica Acta en
dc.identifier.volume 273 en
dc.identifier.issue 1-2 en
dc.identifier.spage 201 en
dc.identifier.epage 203 en

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