The role of O2•- radicals in DNA-metal complexes

Anastassopoulou, JD; Rakintzis, NTh; Theophanides, TM

dc.contributor.author	Anastassopoulou, JD	en
dc.contributor.author	Rakintzis, NTh	en
dc.contributor.author	Theophanides, TM	en
dc.date.accessioned	2014-03-01T01:47:30Z
dc.date.available	2014-03-01T01:47:30Z
dc.date.issued	1998	en
dc.identifier.issn	00201693	en
dc.identifier.uri	http://hdl.handle.net/123456789/25238
dc.relation.uri	http://www.scopus.com/inward/record.url?eid=2-s2.0-0040598959&partnerID=40&md5=529083f8bbf93b28659e82148f810306	en
dc.subject	DNA complexes	en
dc.subject	Platinum complexes	en
dc.subject	Superoxide radicals	en
dc.title	The role of O2•- radicals in DNA-metal complexes	en
heal.type	journalArticle	en
heal.publicationDate	1998	en
heal.abstract	The nucleotide 5′-guanosine monophosphate (5′-GMPNa2) was irradiated with γ-rays in aerated aqueous solutions in the absence as well as in the presence of cis-dichlorodiammineplatinum(II) (cis-DDP). The HPLC data of the radiolysis products suggest that O2• radicals reduce the Pt(II) complex formed to Pt(I) complex, which finally releases by disproportionation Pt metal, Pt(0). cis-DDP acts as a radiosensitizer and the irradiation in the presence of cis-DDP leads to the release of the base guanine. © 1998 Elsevier Science S.A. All rights reserved.	en
heal.journalName	Inorganica Chimica Acta	en
dc.identifier.volume	273	en
dc.identifier.issue	1-2	en
dc.identifier.spage	201	en
dc.identifier.epage	203	en