Association of single umbilical artery with congenital malformations of vascular etiology

Pavlopoulos, PM; Konstantinidou, AE; Agapitos, E; Christodoulou, CN; Davaris, P

dc.contributor.author	Pavlopoulos, PM	en
dc.contributor.author	Konstantinidou, AE	en
dc.contributor.author	Agapitos, E	en
dc.contributor.author	Christodoulou, CN	en
dc.contributor.author	Davaris, P	en
dc.date.accessioned	2014-03-01T01:47:33Z
dc.date.available	2014-03-01T01:47:33Z
dc.date.issued	1998	en
dc.identifier.issn	1093-5266	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/25255
dc.subject	anorectal atresia	en
dc.subject	esophageal atresia	en
dc.subject	limb reduction defect	en
dc.subject	renal aplasia	en
dc.subject	single umbilical artery	en
dc.subject.classification	Pathology	en
dc.subject.classification	Pediatrics	en
dc.subject.other	FETUSES	en
dc.subject.other	DEFECTS	en
dc.subject.other	SIRENOMELIA	en
dc.subject.other	ANOMALIES	en
dc.title	Association of single umbilical artery with congenital malformations of vascular etiology	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	1998	en
heal.abstract	The possible association of a single umbilical artery (SUA) with malformations of vascular etiology is investigated in this study. Four hundred twelve fetal and embryonic autopsies showing one or more congenital malformations, collected over 7 years, were reviewed. Microscopic confirmation of a SUA was evident in 20 cases (4.85%). The two subgroups with 2 (n(A) = 20) or 3 umbilical vessels (n(B) = 392) were compared with each other, in relation to the frequency of malformations per organ system. In the group of fetuses with congenital malformations, no association was observed between SUA and the incidence of CNS, cardiac, pulmonary, or genital malformations. However, there was a significantly higher incidence of atresia of hollow organs (P = 0.003), renal aplasia (P = 0.034), and limb reduction defects (LRD) (P = 0.0383) when only a single umbilical artery was present. This suggests a possible etiopathogenetic association of SUA with congenital malformations of vascular etiology. Furthermore, the findings of our study suggest that prenatal identification of a SUA warrants a thorough search for atresias, renal aplasia, and LRD-type malformations.	en
heal.publisher	SPRINGER VERLAG	en
heal.journalName	PEDIATRIC AND DEVELOPMENTAL PATHOLOGY	en
dc.identifier.isi	ISI:000077198400004	en
dc.identifier.volume	1	en
dc.identifier.issue	6	en
dc.identifier.spage	487	en
dc.identifier.epage	493	en