Hypofunction of the stress axis in Sjogren's syndrome

Johnson, EO; Vlachoyiannopoulos, PG; Skopouli, FN; Tzioufas, AG; Moutsopoulos, HM

dc.contributor.author	Johnson, EO	en
dc.contributor.author	Vlachoyiannopoulos, PG	en
dc.contributor.author	Skopouli, FN	en
dc.contributor.author	Tzioufas, AG	en
dc.contributor.author	Moutsopoulos, HM	en
dc.date.accessioned	2014-03-01T01:47:36Z
dc.date.available	2014-03-01T01:47:36Z
dc.date.issued	1998	en
dc.identifier.issn	0315-162X	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/25270
dc.subject	stress axis	en
dc.subject	Sjogren's syndrome	en
dc.subject	cortisol	en
dc.subject	ACTH	en
dc.subject.classification	Rheumatology	en
dc.subject.other	CORTICOTROPIN-RELEASING HORMONE	en
dc.subject.other	PITUITARY-ADRENAL AXIS	en
dc.subject.other	RHEUMATOID-ARTHRITIS	en
dc.subject.other	BEHAVIORAL HOMEOSTASIS	en
dc.subject.other	CUSHINGS-DISEASE	en
dc.subject.other	LEWIS RATS	en
dc.subject.other	RESPONSES	en
dc.subject.other	SYSTEM	en
dc.subject.other	DEXAMETHASONE	en
dc.subject.other	ACTIVATION	en
dc.title	Hypofunction of the stress axis in Sjogren's syndrome	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	1998	en
heal.abstract	Objective. To examine the functional integrity of the hypothalamic-pituitary-adrenal (HPA) and thyroid axes in Sjogren's syndrome (SS) via the assessment of basal and stimulated adrenocorticotropin (ACTH), cortisol, thyroid stimulating hormone (TSH), and prolactin levels. Methods. Pituitary function of the HPA axis was assessed by determining the basal plasma levels of ACTH in the late afternoon, as well as the ACTH released to ovine corticotropin releasing hormone (oCRH) stimulation; adrenal function was assessed by measuring plasma cortisol levels in the late afternoon at baseline and after release of the endogenous ACTH during oCRH stimulation. Basal and thyrotropin releasing hormone (TRH) stimulated levels of TSH and prolactin were also assessed. Healthy volunteers were used as controls. Results. Patients with SS, compared to controls, were characterized by significantly lower ACTH levels (pg/ml), (5.1 +/- 0.5 vs 11.4 +/- 1.5, respectively; p < 0.05) and cortisol levels (mu g/ml), (2.4 +/- 0.6 vs 5.9 +/- 1.2, respectively; p < 0.05), Furthermore, a blunted pituitary and adrenal response to oCRH compared to controls was observed: peak plasma ACTH and cortisol levels for patients with SS were 46.2 +/- 5.4 pg/ml and 15.7 +/- 1.6 mu g/ml, respectively, and for controls 61.5 +/- 3.8 and 19.6 +/- 0.7, respectively (p < 0.05). Basal TSH levels were significantly elevated in patients (1.3 +/- 0.3 mu IU/ml vs 0.9 +/- 0.05 mu IU/ml; p < 0.05). Conclusion, The above findings indicate hypoactivity of the HPA axis in patients with SS. Further studies are needed to definitively identify the locus of the defects and assess the significance of the pattern of the perturbations to the pathogenesis and expression of SS.	en
heal.publisher	J RHEUMATOL PUBL CO	en
heal.journalName	JOURNAL OF RHEUMATOLOGY	en
dc.identifier.isi	ISI:000075104100012	en
dc.identifier.volume	25	en
dc.identifier.issue	8	en
dc.identifier.spage	1508	en
dc.identifier.epage	1514	en