The role of O-2(center dot-) radicals in DNA-metal complexes

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dc.contributor.author Anastassopoulou, JD en
dc.contributor.author Rakintzis, NT en
dc.contributor.author Theophanides, TM en
dc.date.accessioned 2014-03-01T01:47:44Z
dc.date.available 2014-03-01T01:47:44Z
dc.date.issued 1998 en
dc.identifier.issn 0020-1693 en
dc.identifier.uri https://dspace.lib.ntua.gr/xmlui/handle/123456789/25303
dc.subject superoxide radicals en
dc.subject platinum complexes en
dc.subject DNA complexes en
dc.subject.classification Chemistry, Inorganic & Nuclear en
dc.subject.other RADIATION en
dc.title The role of O-2(center dot-) radicals in DNA-metal complexes en
heal.type journalArticle en
heal.language English en
heal.publicationDate 1998 en
heal.abstract The nucleotide 5'-guanosine monophosphate (5'-GMPNa(2)) was irradiated with gamma-rays in aerated aqueous solutions in the absence as well as in the presence of cis-dichlorodiammineplatinum(II) (cis-DDP). The HPLC data of the radiolysis products suggest that O-2(.-) radicals reduce the Pt(II) complex formed to Pt(I) complex, which finally releases by disproportionation Pt metal, Pt(0). cis-DDP acts as a radiosensitizer and the irradiation in the presence of cis-DDP leads to the release of the base guanine. (C) 1998 Elsevier Science S.A. All rights reserved. en
heal.publisher ELSEVIER SCIENCE SA en
dc.identifier.isi ISI:000073728200028 en
dc.identifier.volume 273 en
dc.identifier.issue 1-2 en
dc.identifier.spage 201 en
dc.identifier.epage 203 en

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