The role of O-2(center dot-) radicals in DNA-metal complexes

Anastassopoulou, JD; Rakintzis, NT; Theophanides, TM

dc.contributor.author	Anastassopoulou, JD	en
dc.contributor.author	Rakintzis, NT	en
dc.contributor.author	Theophanides, TM	en
dc.date.accessioned	2014-03-01T01:47:44Z
dc.date.available	2014-03-01T01:47:44Z
dc.date.issued	1998	en
dc.identifier.issn	0020-1693	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/25303
dc.subject	superoxide radicals	en
dc.subject	platinum complexes	en
dc.subject	DNA complexes	en
dc.subject.classification	Chemistry, Inorganic & Nuclear	en
dc.subject.other	RADIATION	en
dc.title	The role of O-2(center dot-) radicals in DNA-metal complexes	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	1998	en
heal.abstract	The nucleotide 5'-guanosine monophosphate (5'-GMPNa(2)) was irradiated with gamma-rays in aerated aqueous solutions in the absence as well as in the presence of cis-dichlorodiammineplatinum(II) (cis-DDP). The HPLC data of the radiolysis products suggest that O-2(.-) radicals reduce the Pt(II) complex formed to Pt(I) complex, which finally releases by disproportionation Pt metal, Pt(0). cis-DDP acts as a radiosensitizer and the irradiation in the presence of cis-DDP leads to the release of the base guanine. (C) 1998 Elsevier Science S.A. All rights reserved.	en
heal.publisher	ELSEVIER SCIENCE SA	en
heal.journalName	INORGANICA CHIMICA ACTA	en
dc.identifier.isi	ISI:000073728200028	en
dc.identifier.volume	273	en
dc.identifier.issue	1-2	en
dc.identifier.spage	201	en
dc.identifier.epage	203	en