Dosimetry in photodynamic therapy and laser induced fluorescence spectroscopy

Drakaki, E; Makropoulou, M; Mallas, E; Serafetinides, AA

dc.contributor.author	Drakaki, E	en
dc.contributor.author	Makropoulou, M	en
dc.contributor.author	Mallas, E	en
dc.contributor.author	Serafetinides, AA	en
dc.date.accessioned	2014-03-01T01:48:32Z
dc.date.available	2014-03-01T01:48:32Z
dc.date.issued	1999	en
dc.identifier.issn	0277786X	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/25514
dc.relation.uri	http://www.scopus.com/inward/record.url?eid=2-s2.0-0032655435&partnerID=40&md5=c4b42c331c0bf95fee1336569fe49e94	en
dc.subject.other	Dosimetry	en
dc.subject.other	Drug therapy	en
dc.subject.other	Fluorescence	en
dc.subject.other	Laser applications	en
dc.subject.other	Light absorption	en
dc.subject.other	Mathematical models	en
dc.subject.other	Optical recording	en
dc.subject.other	Photosensitizers	en
dc.subject.other	Simulators	en
dc.subject.other	Spectrophotometers	en
dc.subject.other	Tissue	en
dc.subject.other	Drug concentration	en
dc.subject.other	Laser dosimetry	en
dc.subject.other	Laser induced fluorescence spectroscopy	en
dc.subject.other	Soft tissue simulators	en
dc.subject.other	Photodynamic therapy	en
dc.title	Dosimetry in photodynamic therapy and laser induced fluorescence spectroscopy	en
heal.type	journalArticle	en
heal.publicationDate	1999	en
heal.abstract	Many factors are involved in a relatively new tumour treatment modality, the photodynamic therapy (PDT). Among them the most important are the laser parameters (wavelength, energy fluence), the photosensitizer cytotoxic and optical properties, the delay between drug injection and PDT and the effective dosimetry of both light and drug distribution in the treatment target. In this work, we compare the effectiveness of two methods of predicting the concentration of the photosensitizer m-THPC in tissue simulators. In the first method, a conventional double beam spectrophotometer was used to measure the absorption in UV-VIS of the soft tissue simulators, prepared with agar gel with different concentration of m-THPC. In the second method, the laser induced fluorescence spectra of these samples were recorded and an effort was made to determine from these the optical properties of the samples, in order to calculate the required drug concentration in vitro. The experimental results are discussed in conjunction with the appropriate theoretical models.	en
heal.publisher	Society of Photo-Optical Instrumentation Engineers, Bellingham, WA, United States	en
heal.journalName	Proceedings of SPIE - The International Society for Optical Engineering	en
dc.identifier.volume	3571	en
dc.identifier.spage	392	en
dc.identifier.epage	396	en