Fluorescence diagnosis of colon cancer using two novel Rhodamine B derivatives

Atlamazoglou, V; Yova, D; Kavantzas, N; Loukas, S

dc.contributor.author	Atlamazoglou, V	en
dc.contributor.author	Yova, D	en
dc.contributor.author	Kavantzas, N	en
dc.contributor.author	Loukas, S	en
dc.date.accessioned	2014-03-01T01:48:36Z
dc.date.available	2014-03-01T01:48:36Z
dc.date.issued	1999	en
dc.identifier.issn	0277786X	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/25525
dc.relation.uri	http://www.scopus.com/inward/record.url?eid=2-s2.0-0032682765&partnerID=40&md5=c2a6cb4031c0c86e2ba69d16fe10329e	en
dc.subject.other	Fluorescence	en
dc.subject.other	Oncology	en
dc.subject.other	Optical microscopy	en
dc.subject.other	Tissue	en
dc.subject.other	Fluorescence diagnosis	en
dc.subject.other	Histology	en
dc.subject.other	Rhodamine derivatives	en
dc.subject.other	Medical imaging	en
dc.title	Fluorescence diagnosis of colon cancer using two novel Rhodamine B derivatives	en
heal.type	journalArticle	en
heal.publicationDate	1999	en
heal.abstract	Fluorescence imaging is a promising technique for the early detection of neoplastic changes in the human body. Investigation of the microscopic origin of tissue fluorescence can provide important information about the histology of tissue. In this study we report the synthesis and use of two novel Rhodamine B derivatives in an efficient microscopic technique for colon cancer diagnosis. Another important objective is the examination of the morphological structures on which the fluorescence analogs bind and the correlation of the fluorescence images with their underlying microstructural origin. Rh B - Leucine amide and Rh B - phenyl boronic acid distinguish clearly healthy from neoplastic colon tissue sections. Both derivatives accumulate mainly in the of neoplastic crypts. This finding can be exploited for colon cancer diagnosis using fluorescence microscopy as well as for a fluorescence-based optical biopsy method.	en
heal.publisher	Society of Photo-Optical Instrumentation Engineers, Bellingham, WA, United States	en
heal.journalName	Proceedings of SPIE - The International Society for Optical Engineering	en
dc.identifier.volume	3568	en
dc.identifier.spage	2	en
dc.identifier.epage	10	en