Photodynamic treatment of pancreatic cancer cells: Genotoxicity and chromosome damage induced by red light and zinc tetrasulfonated phthalocyanines (ZnPcS4)

Halkiotis Konstantinos, N; Yova Dido, K; Pantelias Gabriel, E

dc.contributor.author	Halkiotis Konstantinos, N	en
dc.contributor.author	Yova Dido, K	en
dc.contributor.author	Pantelias Gabriel, E	en
dc.date.accessioned	2014-03-01T01:48:42Z
dc.date.available	2014-03-01T01:48:42Z
dc.date.issued	1999	en
dc.identifier.issn	0277786X	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/25565
dc.relation.uri	http://www.scopus.com/inward/record.url?eid=2-s2.0-0032659207&partnerID=40&md5=4529a91860d19be742389f8f6b634228	en
dc.subject.other	Cytology	en
dc.subject.other	Drug products	en
dc.subject.other	Genes	en
dc.subject.other	Laser tissue interaction	en
dc.subject.other	Oncology	en
dc.subject.other	Photodynamic therapy	en
dc.subject.other	Semiconductor lasers	en
dc.subject.other	Toxicity	en
dc.subject.other	Zinc compounds	en
dc.subject.other	Genotoxicity	en
dc.subject.other	Zinc tetrasulfonated phthalocyanine	en
dc.subject.other	Biomedical engineering	en
dc.title	Photodynamic treatment of pancreatic cancer cells: Genotoxicity and chromosome damage induced by red light and zinc tetrasulfonated phthalocyanines (ZnPcS4)	en
heal.type	journalArticle	en
heal.publicationDate	1999	en
heal.abstract	PDT relies on the combined action of photosensitizers localized on tumours and activated under laser light. Tumour cells response to PDT is determined by both the photosensitizer and the photoirradiation dose. However, the processes governing the resultant tumour destruction are still unknown and recent advances in the field of cellular biology have stimulated the research interest in this field. In this paper, the genotoxicity and chromosome damage on MIA pancreatic cancer cells, induced by red light and zinc tetrasulfonated phthalocyanines (ZnPcS4) was studied. The results showed that cells treated with a low concentration (1 μM) of ZnPcS4 and a light dose of 6 J/cm2 indicated more than 70% lethality, 72 hrs after irradiation. The SCE assay, showed that treated cells with various light and drug doses, presented no genotoxic potential, as far as SCE levels were not different from those of the untreated (control) cells. Chromosomal analysis after optimum PDT treatment in various time intervals post irradiation, showed that there was not any significant chromosomal damage on cells, compared to the untreated (control) cells.	en
heal.publisher	Society of Photo-Optical Instrumentation Engineers, Bellingham, WA, United States	en
heal.journalName	Proceedings of SPIE - The International Society for Optical Engineering	en
dc.identifier.volume	3563	en
dc.identifier.spage	38	en
dc.identifier.epage	49	en