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HLA associations of anti-beta2 glycoprotein I response in a Greek cohort with antiphospholipid syndrome and meta-analysis of four ethnic groups

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dc.contributor.author Ioannidis, JPA en
dc.contributor.author Tektonidou, MG en
dc.contributor.author Vlachoyiannopoulos, PG en
dc.contributor.author Stavropoulos-Giokas, C en
dc.contributor.author Spyropoulou-Vlachou, M en
dc.contributor.author Reveille, JD en
dc.contributor.author Arnett, FC en
dc.contributor.author Moutsopoulos, HM en
dc.date.accessioned 2014-03-01T01:48:53Z
dc.date.available 2014-03-01T01:48:53Z
dc.date.issued 1999 en
dc.identifier.issn 0198-8859 en
dc.identifier.uri https://dspace.lib.ntua.gr/xmlui/handle/123456789/25629
dc.subject antiphospholipid syndrome en
dc.subject beta-2 glycoprotein I en
dc.subject class IIHLA alleles en
dc.subject meta-analysis en
dc.subject.classification Immunology en
dc.subject.other SYSTEMIC LUPUS-ERYTHEMATOSUS en
dc.subject.other ANTICARDIOLIPIN ANTIBODIES en
dc.subject.other CRITERIA en
dc.subject.other DISEASE en
dc.subject.other ANTI-BETA(2)-GLYCOPROTEIN-I en
dc.subject.other BETA-2-GLYCOPROTEIN-I en
dc.subject.other CLASSIFICATION en
dc.subject.other ANTICOAGULANTS en
dc.subject.other THROMBOSIS en
dc.subject.other POLYMERASE en
dc.title HLA associations of anti-beta2 glycoprotein I response in a Greek cohort with antiphospholipid syndrome and meta-analysis of four ethnic groups en
heal.type journalArticle en
heal.language English en
heal.publicationDate 1999 en
heal.abstract Using molecular typing, we evaluated the strength of class II HLA associations in 67 Greek patients with antiphospholipid syndrome (APS), 54 of whom had antibodies against beta 2-glycoprotein I (beta 2GPI), as compared to 246 controls. To further clarify and delineate HLA associations of the beta 2GPI response, we combined these data with individual patient data From three other ethnic groups including an additional 74 patients with beta 2GPI response and 403 ethnically matched controls of white, African-American, and Mexican-American origin in a Formal meta-analysis. The major alleles associated with anti-beta 2GPI response are HLA-DQA1*03 (in particular *0301) and the HLA-DRB1*1302-DQB1*0604 haplotype, while protection against developing an anti-beta 2GPI response is related primarily to the HLA-DRB1*0101-DQA1*0101 haplotype and the the HLA-DRB1*1101 allele. These effects are not significantly heterogeneous across ethnic groups. The previously observed association with HLA-DQB1*0302 may simply reflect linkage disequilibrium with HLA-DQA1*0301 and the previously reported HLA-DQB1*06 effect is limited to HLA-DQB1*0604/0605, while HLA-DQB1*0602 is unlikely to be important. The metaanalysis clearly documents that the anti-beta 2GPI response is determined by a few specific class II alleles and haplotypes. (C) American Society for Histocompatibility and Immunogenetics, 1999. Published by Elsevier Science Inc. en
heal.publisher ELSEVIER SCIENCE INC en
heal.journalName HUMAN IMMUNOLOGY en
dc.identifier.isi ISI:000084355100011 en
dc.identifier.volume 60 en
dc.identifier.issue 12 en
dc.identifier.spage 1274 en
dc.identifier.epage 1280 en


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