ACE/DD genotype is associated with hemostasis balance disturbances reflecting hypercoagulability and endothelial dysfunction in patients with untreated hypertension

Makris, TK; Stavroulakis, GA; Dafni, UG; Gialeraki, AE; Krespi, PG; Hatzizacharias, AN; Tsoukala, CG; Vythoulkas, JS; Kyriakidis, MK

dc.contributor.author	Makris, TK	en
dc.contributor.author	Stavroulakis, GA	en
dc.contributor.author	Dafni, UG	en
dc.contributor.author	Gialeraki, AE	en
dc.contributor.author	Krespi, PG	en
dc.contributor.author	Hatzizacharias, AN	en
dc.contributor.author	Tsoukala, CG	en
dc.contributor.author	Vythoulkas, JS	en
dc.contributor.author	Kyriakidis, MK	en
dc.date.accessioned	2014-03-01T01:49:45Z
dc.date.available	2014-03-01T01:49:45Z
dc.date.issued	2000	en
dc.identifier.issn	0002-8703	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/25903
dc.subject.classification	Cardiac & Cardiovascular Systems	en
dc.subject.other	ANGIOTENSIN-CONVERTING ENZYME	en
dc.subject.other	PLASMINOGEN-ACTIVATOR INHIBITOR-1	en
dc.subject.other	CORONARY-ARTERY DISEASE	en
dc.subject.other	ISCHEMIC-HEART-DISEASE	en
dc.subject.other	GENE POLYMORPHISM	en
dc.subject.other	MYOCARDIAL-INFARCTION	en
dc.subject.other	BORDERLINE HYPERTENSION	en
dc.subject.other	FIBRINOLYTIC BALANCE	en
dc.subject.other	CELL DAMAGE	en
dc.subject.other	RISK	en
dc.title	ACE/DD genotype is associated with hemostasis balance disturbances reflecting hypercoagulability and endothelial dysfunction in patients with untreated hypertension	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2000	en
heal.abstract	Background Angiotensin-converting enzyme (ACE) gene polymorphism has been associated with an increased incidence of myocardial infarction. Recent studies have investigated a potential influence of ACE gene polymorphism on fibrinolysis or endothelial function. It has been previously established that essential hypertension is accompanied by endothelial dysfunction and fibrinolytic balance disorders. The aim of our study was to study the relation between ACE gene polymorphism and fibrinolytic/hemostatic factors as well as endothelial cell damage markers in patients with hypertension. Methods The following parameters were evaluated in 104 patients with previously untreated hypertension: plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator (IPA) antigen, fibrinogen, D-dimer, and von Willebrand factor (vWF). The genotype of the ACE gene was also determined (by the polymerase chain reaction method), and patients were characterized according to the observed alleles as deletion/deletion IDD), insertion/insertion till, or insertion/deletion (ID). Results Those with DD genotype tn = 42) had significantly higher plasma levels of PAI-I antigen (P = .012), IPA antigen (P = .0001), fibrinogen (P = .0002), D-dimer (P = .0001) and VWF (P = .0004) compared with ID (n = 30) or II (n = 32) genotypes. The ACE gene genotypes appeared to be significant predictors for plasma PAI-1 antigen, tPA antigen, fibrinogen, D-dimer, and VWF even after adjustment for age, sex, body mass index, triglyceride and cholesterol levels, and blood pressure. Conclusions Our findings suggest that the ACE/DD genotype is associated with hemostasis balance disturbances reflecting hypercoagulability and endothelial damage in patients with untreated hypertension.	en
heal.publisher	MOSBY, INC	en
heal.journalName	AMERICAN HEART JOURNAL	en
dc.identifier.isi	ISI:000165075200010	en
dc.identifier.volume	140	en
dc.identifier.issue	5	en
dc.identifier.spage	760	en
dc.identifier.epage	765	en