Polymers for use in controlled release systems: The effect of surfactants on their swelling properties

Vlachou, M; Hani, N; Efentakis, M; Tarantili, PA; Andreopoulos, AG

dc.contributor.author	Vlachou, M	en
dc.contributor.author	Hani, N	en
dc.contributor.author	Efentakis, M	en
dc.contributor.author	Tarantili, PA	en
dc.contributor.author	Andreopoulos, AG	en
dc.date.accessioned	2014-03-01T01:50:07Z
dc.date.available	2014-03-01T01:50:07Z
dc.date.issued	2000	en
dc.identifier.issn	0885-3282	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/26000
dc.subject	controlled release	en
dc.subject	surfactant	en
dc.subject	swelling	en
dc.subject	polymeric drug carriers	en
dc.subject.classification	Engineering, Biomedical	en
dc.subject.classification	Materials Science, Biomaterials	en
dc.subject.other	BIODEGRADABLE SYSTEMS	en
dc.subject.other	POLY(LACTIC ACID)	en
dc.subject.other	DRUG-DELIVERY	en
dc.subject.other	IN-VITRO	en
dc.subject.other	QUINOLONES	en
dc.subject.other	MATRICES	en
dc.title	Polymers for use in controlled release systems: The effect of surfactants on their swelling properties	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2000	en
heal.abstract	The effect of an ampholytic surfactant on the swelling properties of polymeric materials was studied, using various swelling liquids. Tablets were prepared consisting of hydroxypropyl methylcellulose, poly(oxyethylene) and sodium alginate. Tego betain was the non-ionic surfactant used as an additive in a series of samples made of the above polymers. Those tablets were immersed in distilled water, phosphate buffer and 0.1 N HCl, and their weight uptake was recorded as a function of time, in order to assess the swelling process. Measurements of the contact angle of the above systems were also carried out for estimating their wetting properties. The results of this study showed a selectivity among polymers, surfactant and surrounding liquid. Clearly, an enhancement of the swelling capacity of hydroxypropyl methylcellulose tablets due to the surfactant was recorded. An unclear effect was observed in the case of poly(oxyethylene), whereas for sodium alginate, the dominant factor is its water solubility that controls swelling behaviour.	en
heal.publisher	TECHNOMIC PUBL CO INC	en
heal.journalName	JOURNAL OF BIOMATERIALS APPLICATIONS	en
dc.identifier.isi	ISI:000088813300004	en
dc.identifier.volume	15	en
dc.identifier.issue	1	en
dc.identifier.spage	65	en
dc.identifier.epage	77	en