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Reactions of N-hydroxysuccinimide esters of anthranilic acids with anions of beta-keto esters. A new route to 4-oxo-3-quinolinecarboxylic acid derivatives

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dc.contributor.author Mitsos, C en
dc.contributor.author Zografos, A en
dc.contributor.author Igglessi-Markopoulou, O en
dc.date.accessioned 2014-03-01T01:50:09Z
dc.date.available 2014-03-01T01:50:09Z
dc.date.issued 2000 en
dc.identifier.issn 0009-2363 en
dc.identifier.uri https://dspace.lib.ntua.gr/xmlui/handle/123456789/26007
dc.subject quinolones en
dc.subject N-hydroxysuccinimide esters en
dc.subject C-acylation reaction en
dc.subject.classification Chemistry, Medicinal en
dc.subject.classification Chemistry, Multidisciplinary en
dc.subject.classification Pharmacology & Pharmacy en
dc.subject.other PYRIDONECARBOXYLIC ACIDS en
dc.subject.other 4-HYDROXY-3-QUINOLINECARBOXAMIDES en
dc.subject.other 3-QUINOLINECARBOXAMIDES en
dc.subject.other 4-QUINOLONE en
dc.subject.other AGENTS en
dc.title Reactions of N-hydroxysuccinimide esters of anthranilic acids with anions of beta-keto esters. A new route to 4-oxo-3-quinolinecarboxylic acid derivatives en
heal.type journalArticle en
heal.language English en
heal.publicationDate 2000 en
heal.abstract A new approach for the synthesis of 4-oxo-3-quinolinecarboxylic acid derivatives is described. This methodology involves the C-acylation of the anions of appropriate beta-keto esters with novel N-hydroxysuccinimide esters of anthranilic acids. The intermediate C-acylation products 3 are spontaneously cyclized to afford 3-ethoxycarbonyl-4-oxoquinoline derivatives 4, The introduction of a variety of substituents at positions 1 and 2 of the quinoline ring is feasible with the selection of suitable anthranilic acids and beta-keto esters. The structure of the obtained 2-substituted 3-ethoxycarbonyl-4-oxoquinolines was confirmed by IR and NMR spectral data. en
heal.publisher PHARMACEUTICAL SOC JAPAN en
heal.journalName CHEMICAL & PHARMACEUTICAL BULLETIN en
dc.identifier.isi ISI:000085234800008 en
dc.identifier.volume 48 en
dc.identifier.issue 2 en
dc.identifier.spage 211 en
dc.identifier.epage 214 en


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