Reactions of N-hydroxysuccinimide esters of anthranilic acids with anions of beta-keto esters. A new route to 4-oxo-3-quinolinecarboxylic acid derivatives

Mitsos, C; Zografos, A; Igglessi-Markopoulou, O

dc.contributor.author	Mitsos, C	en
dc.contributor.author	Zografos, A	en
dc.contributor.author	Igglessi-Markopoulou, O	en
dc.date.accessioned	2014-03-01T01:50:09Z
dc.date.available	2014-03-01T01:50:09Z
dc.date.issued	2000	en
dc.identifier.issn	0009-2363	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/26007
dc.subject	quinolones	en
dc.subject	N-hydroxysuccinimide esters	en
dc.subject	C-acylation reaction	en
dc.subject.classification	Chemistry, Medicinal	en
dc.subject.classification	Chemistry, Multidisciplinary	en
dc.subject.classification	Pharmacology & Pharmacy	en
dc.subject.other	PYRIDONECARBOXYLIC ACIDS	en
dc.subject.other	4-HYDROXY-3-QUINOLINECARBOXAMIDES	en
dc.subject.other	3-QUINOLINECARBOXAMIDES	en
dc.subject.other	4-QUINOLONE	en
dc.subject.other	AGENTS	en
dc.title	Reactions of N-hydroxysuccinimide esters of anthranilic acids with anions of beta-keto esters. A new route to 4-oxo-3-quinolinecarboxylic acid derivatives	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2000	en
heal.abstract	A new approach for the synthesis of 4-oxo-3-quinolinecarboxylic acid derivatives is described. This methodology involves the C-acylation of the anions of appropriate beta-keto esters with novel N-hydroxysuccinimide esters of anthranilic acids. The intermediate C-acylation products 3 are spontaneously cyclized to afford 3-ethoxycarbonyl-4-oxoquinoline derivatives 4, The introduction of a variety of substituents at positions 1 and 2 of the quinoline ring is feasible with the selection of suitable anthranilic acids and beta-keto esters. The structure of the obtained 2-substituted 3-ethoxycarbonyl-4-oxoquinolines was confirmed by IR and NMR spectral data.	en
heal.publisher	PHARMACEUTICAL SOC JAPAN	en
heal.journalName	CHEMICAL & PHARMACEUTICAL BULLETIN	en
dc.identifier.isi	ISI:000085234800008	en
dc.identifier.volume	48	en
dc.identifier.issue	2	en
dc.identifier.spage	211	en
dc.identifier.epage	214	en