Sjogren's syndrome: autoimmune epithelitis

Manoussakis, MN; Moutsopoulos, HM

dc.contributor.author	Manoussakis, MN	en
dc.contributor.author	Moutsopoulos, HM	en
dc.date.accessioned	2014-03-01T01:50:20Z
dc.date.available	2014-03-01T01:50:20Z
dc.date.issued	2000	en
dc.identifier.issn	1521-6942	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/26022
dc.subject	Sjogren's syndrome	en
dc.subject	autoimmune epithelitis	en
dc.subject	autoimmune exocrinopathy	en
dc.subject	autoimmune rheumatic diseases	en
dc.subject	exocrine glands	en
dc.subject	epithelial cells	en
dc.subject	primary Sjogren's syndrome	en
dc.subject	secondary Sjogren's syndrome	en
dc.subject	lymphoma	en
dc.subject	autoantibodies	en
dc.subject	diagnosis	en
dc.subject	differential diagnosis	en
dc.subject	severity index	en
dc.subject.classification	Rheumatology	en
dc.subject.other	SICCA SYNDROME	en
dc.subject.other	LYMPHOMA	en
dc.subject.other	MANIFESTATIONS	en
dc.subject.other	CLASSIFICATION	en
dc.subject.other	ABNORMALITIES	en
dc.subject.other	HYPOFUNCTION	en
dc.subject.other	SIALADENITIS	en
dc.subject.other	INVOLVEMENT	en
dc.subject.other	PREVALENCE	en
dc.subject.other	EXPRESSION	en
dc.title	Sjogren's syndrome: autoimmune epithelitis	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2000	en
heal.abstract	Sjogren's syndrome (SS) is a chronic autoimmune disorder of the exocrine glands of unknown aetiology, which is typically associated with focal]lymphocytic infiltrates of glandular tissues and autoantibody responses against the Ro(SSA) and La(SSB) ribonucleoproteins. In almost one-third of patients disease involves various extraglandular sites, whereas approximately 5% of patients may also develop malignant B-cell lymphoma. In addition, features of SS are frequently encountered (5-20%) in patients with several other autoimmune rheumatic diseases, and in several respects these 'secondary' forms may be distinct from SS found alone (primary-SS), as well as from each other. The correct diagnosis and management of SS may require consideration from various specialists. Differential diagnosis includes adverse effects of drugs, sarcoidosis, lipoproteinaemias, age-related atrophy, chronic graft-versus-host disease, lymphomas, amyloidosis and infection by human immunodeficiency virus or hepatitis C virus. Based on the sequential application of the validated European classification criteria for SS, a practical algorithm for diagnosis is presented. Despite progress in the understanding of the broad clinicopathological spectrum of the entity, its treatment remains largely empirical and symptomatic. To date, the decision for systemic therapeutic intervention is primarily based on the severity of extraglandular manifestations.	en
heal.publisher	BAILLIERE TINDALL	en
heal.journalName	BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY	en
dc.identifier.isi	ISI:000087481400005	en
dc.identifier.volume	14	en
dc.identifier.issue	1	en
dc.identifier.spage	73	en
dc.identifier.epage	95	en