Hyperosmotic stress induces volume change and calcium transients in chondrocytes by transmembrane, phospholipid, and G-protein pathways

Erickson, G; Alexopoulos, L; Guilak, F

dc.contributor.author	Erickson, G	en
dc.contributor.author	Alexopoulos, L	en
dc.contributor.author	Guilak, F	en
dc.date.accessioned	2014-03-01T01:50:45Z
dc.date.available	2014-03-01T01:50:45Z
dc.date.issued	2001	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/26115
dc.subject	Articular Cartilage	en
dc.subject	Calcium Transient	en
dc.subject	Cell Volume	en
dc.subject	Digital Image Processing	en
dc.subject	G Protein	en
dc.subject	intracellular ca2+	en
dc.subject	Intracellular Calcium	en
dc.subject	Ion Channel	en
dc.subject	Laser Scanning Microscopy	en
dc.subject	Oscillations	en
dc.subject	Osmotic Pressure	en
dc.subject	Osmotic Stress	en
dc.subject	Osteoarthritis	en
dc.subject	Second Messengers	en
dc.subject	Volume Change	en
dc.subject	Inositol Phosphate	en
dc.subject	Pertussis Toxin	en
dc.title	Hyperosmotic stress induces volume change and calcium transients in chondrocytes by transmembrane, phospholipid, and G-protein pathways	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/S0021-9290(01)00156-7	en
heal.identifier.secondary	http://dx.doi.org/10.1016/S0021-9290(01)00156-7	en
heal.publicationDate	2001	en
heal.abstract	Mechanical compression of cartilage is associated with a rise in the interstitial osmotic pressure, which can alter cell volume and activate volume recovery pathways. One of the early events implicated in regulatory volume changes and mechanotransduction is an increase of intracellular calcium ion ([Ca2+]i). In this study, we tested the hypothesis that osmotic stress initiates intracellular Ca2+ signaling in chondrocytes.	en
heal.journalName	Journal of Biomechanics	en
dc.identifier.doi	10.1016/S0021-9290(01)00156-7	en