European multicentre study to define disease activity criteria for systemic sclerosis. II. Identification of disease activity variables and development of preliminary activity indexes

Valentini, G; Della Rossa, A; Bombardieri, S; Bencivelli, W; Silman, AJ; D'Angelo, S; Cerinic, MM; Belch, JF; Black, CM; Bruhlmann, P; Czirjak, L; De Luca, A; Drosos, AA; Ferri, C; Gabrielli, A; Giacomelli, R; Hayem, G; Inanc, M; McHugh, NJ; Nielsen, H; Rosada, M; Scorza, R; Stork, J; Sysa, A; van den Hoogen, FHJ; Vlachoyiannopoulos, PJ

dc.contributor.author	Valentini, G	en
dc.contributor.author	Della Rossa, A	en
dc.contributor.author	Bombardieri, S	en
dc.contributor.author	Bencivelli, W	en
dc.contributor.author	Silman, AJ	en
dc.contributor.author	D'Angelo, S	en
dc.contributor.author	Cerinic, MM	en
dc.contributor.author	Belch, JF	en
dc.contributor.author	Black, CM	en
dc.contributor.author	Bruhlmann, P	en
dc.contributor.author	Czirjak, L	en
dc.contributor.author	De Luca, A	en
dc.contributor.author	Drosos, AA	en
dc.contributor.author	Ferri, C	en
dc.contributor.author	Gabrielli, A	en
dc.contributor.author	Giacomelli, R	en
dc.contributor.author	Hayem, G	en
dc.contributor.author	Inanc, M	en
dc.contributor.author	McHugh, NJ	en
dc.contributor.author	Nielsen, H	en
dc.contributor.author	Rosada, M	en
dc.contributor.author	Scorza, R	en
dc.contributor.author	Stork, J	en
dc.contributor.author	Sysa, A	en
dc.contributor.author	van den Hoogen, FHJ	en
dc.contributor.author	Vlachoyiannopoulos, PJ	en
dc.date.accessioned	2014-03-01T01:51:09Z
dc.date.available	2014-03-01T01:51:09Z
dc.date.issued	2001	en
dc.identifier.issn	0003-4967	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/26234
dc.subject.classification	Rheumatology	en
dc.subject.other	CONSENSUS-STUDY-GROUP	en
dc.subject.other	RHEUMATOLOGY RESEARCH	en
dc.subject.other	LUPUS-ERYTHEMATOSUS	en
dc.subject.other	SCLERODERMA	en
dc.subject.other	ACTIVATION	en
dc.subject.other	ARTHRITIS	en
dc.subject.other	SEVERITY	en
dc.subject.other	WORKSHOP	en
dc.title	European multicentre study to define disease activity criteria for systemic sclerosis. II. Identification of disease activity variables and development of preliminary activity indexes	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2001	en
heal.abstract	Objective-To develop criteria for disease activity in systemic sclerosis (SSc) that are valid, reliable, and easy to use. Methods-Investigators from 19 European centres completed a standardised clinical chart for a consecutive number of patients with SSc. Three protocol management members blindly evaluated each chart and assigned a disease activity score on a semiquantitative scale of 0-10. Two of them, in addition, gave a blinded, qualitative evaluation of disease activity ("inactive to moderately active" or "active to very active" disease). Both these evaluations were found to be reliable. A final disease activity score and qualitative evaluation of disease activity were arrived at by consensus for each patient; the former represented the gold standard for subsequent analyses. The correlations between individual items in the chart and this gold standard were then analysed. Results-A total of 290 patients with SSc (117 with diffuse SSc (dSSc) and 173 with limited SSc (lSSc)) were enrolled in the study. The items (including Delta -factors-that is, worsening according to the patient report) that were found to correlate with the gold standard on multiple regression were used to construct three separate 10-point indices of disease activity: (a) Delta -cardiopulmonary (4.0), Delta -skin (3.0), Delta -vascular (2.0), and Delta -articular/muscular (1.0) for patients with dSSc; (b) Delta -skin (2.5), erythrocyte sedimentation rate (ESR) >30 mm/1st h (2.5), Delta -cardiopulmonary (1.5), Delta -vascular (1.0), arthritis (1.0), hypocomplementaemia (1.0), and scleredema (0.5) for lSSc; (c) Delta -cardiopulmonary (2.0), Delta -skin (2.0), ESR >30 mm/1st h (1.5), total skin score >20 (1.0), hypocomplementaemia (1.0), scleredema (0.5), digital necrosis (0.5), Delta -vascular (0.5), arthritis (0.5), TLCO <80% (0.5) for all patients with SSc. The three indexes were validated by the jackknife technique. Finally, receiver operating characteristic curves were constructed in order to define the value of the index with the best discriminant capacity for "active to very active" patients. Conclusions-Three feasible, reliable, and valid preliminary indices to define disease activity in SSc were constructed.	en
heal.publisher	BRITISH MED JOURNAL PUBL GROUP	en
heal.journalName	ANNALS OF THE RHEUMATIC DISEASES	en
dc.identifier.isi	ISI:000168749300012	en
dc.identifier.volume	60	en
dc.identifier.issue	6	en
dc.identifier.spage	592	en
dc.identifier.epage	598	en