Evaluation of recalcification of bone metastases after radiotherapy and IV infusion of Disodium Pamidronate, using image processing techniques. Comparative assessment using measurements of the optical density of plain radiography

Kouloulias, V; Antypas, C; Dardoufas, C; Kouvaris, J; Sandilos, P; Seferlis, S; Matsopoulos, G; Uzunoglu, N; Asvestas, P; Vlahos, L

dc.contributor.author	Kouloulias, V	en
dc.contributor.author	Antypas, C	en
dc.contributor.author	Dardoufas, C	en
dc.contributor.author	Kouvaris, J	en
dc.contributor.author	Sandilos, P	en
dc.contributor.author	Seferlis, S	en
dc.contributor.author	Matsopoulos, G	en
dc.contributor.author	Uzunoglu, N	en
dc.contributor.author	Asvestas, P	en
dc.contributor.author	Vlahos, L	en
dc.date.accessioned	2014-03-01T01:51:09Z
dc.date.available	2014-03-01T01:51:09Z
dc.date.issued	2001	en
dc.identifier.issn	1120-1797	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/26235
dc.subject	image processing	en
dc.subject	optical densitometry	en
dc.subject	bone metastasis	en
dc.subject	radiotherapy and disodium pamidronate	en
dc.subject.classification	Biophysics	en
dc.subject.other	BREAST-CANCER	en
dc.subject.other	TISSUE CHARACTERIZATION	en
dc.subject.other	SKELETAL METASTASES	en
dc.subject.other	LESIONS	en
dc.subject.other	TRIAL	en
dc.title	Evaluation of recalcification of bone metastases after radiotherapy and IV infusion of Disodium Pamidronate, using image processing techniques. Comparative assessment using measurements of the optical density of plain radiography	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2001	en
heal.abstract	The aim of the study was to radiographically monitor the early effect of radiotherapy in conjunction with Disodium Pamidronate (DP), on metastatic bone disease, using image-processing techniques. Eight patients with bone lytic metastasis received radiotherapy with a 6MV linac up to a dose of 30Gy (3Gy per fraction, 5 days a week) combined with 6 monthly sessions of infusional 180mgr of DP. Conventional X-rays of all patients were obtained at every session of the treatment, retaining the same settings for each exposure. Quality assurance of accuracy and precision of X-ray exposure parameters showed acceptable values. The analysis of the image attributes was based on measuring the first order statistics of the gray level histogram such as mean value (MVGLH) and energy (EGLH), in 24 small rectangular areas constituting the region of lytic metastasis. The measurements showed a 35.72 % reduction of EGLH and a 3.17% increase of MVGLH, before and after the combined treatment. Further analysis concerning the measurement of the optical density of the film in the region of lytic metastases at every session of the treatment revealed a reduction up to 29.12% (P < 0.001, Kruskal-Wallis test). The changes in the MVGLH were high correlated with the changes of EGLH in terms of R-s = 0.98 (P < 0.0001, spearmon's-rho test) and furthermore with the changes in optical density in terms of R-s = 0.87 (P < 0.0001, spearman's-rho test). These findings indicate a significant level of reliability for both of the above-mentioned methods and beyond this, an important objective early increase in bone mass and formation, which was difficult to be identified visually by the experts.	en
heal.publisher	ISTITUTI EDITORIALI E POLGRAFICI INTERNAZIONALI	en
heal.journalName	PHYSICA MEDICA	en
dc.identifier.isi	ISI:000167944400003	en
dc.identifier.volume	17	en
dc.identifier.issue	1	en
dc.identifier.spage	17	en
dc.identifier.epage	24	en