Synthesis and biological evaluation of novel daunorubicin-estrogen conjugates

Kasiotis, KM; Magiatis, P; Pratsinis, H; Skaltsounis, AL; Abadji, V; Charalambous, A; Moutsatsou, P; Haroutounian, SA

dc.contributor.author	Kasiotis, KM	en
dc.contributor.author	Magiatis, P	en
dc.contributor.author	Pratsinis, H	en
dc.contributor.author	Skaltsounis, AL	en
dc.contributor.author	Abadji, V	en
dc.contributor.author	Charalambous, A	en
dc.contributor.author	Moutsatsou, P	en
dc.contributor.author	Haroutounian, SA	en
dc.date.accessioned	2014-03-01T01:51:20Z
dc.date.available	2014-03-01T01:51:20Z
dc.date.issued	2001	en
dc.identifier.issn	0039-128X	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/26268
dc.subject	daunorubicin conjugates	en
dc.subject	steroidal and non-steroidal estrogen ligand	en
dc.subject	synthesis	en
dc.subject	estrogen receptor binding	en
dc.subject	cytotoxic activity	en
dc.subject.classification	Biochemistry & Molecular Biology	en
dc.subject.classification	Endocrinology & Metabolism	en
dc.subject.other	CYTO-TOXIC AGENTS	en
dc.subject.other	BINDING-AFFINITY	en
dc.subject.other	CELL-LINE	en
dc.subject.other	RECEPTOR	en
dc.subject.other	COMPLEXES	en
dc.subject.other	GROWTH	en
dc.title	Synthesis and biological evaluation of novel daunorubicin-estrogen conjugates	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2001	en
heal.abstract	The synthesis of two novel daunorubicin-estro-en conjugates with a steroidal and a non-steroidal ligand was undertaken in an attempt to target the cytotoxicity of anthracycline to estrogen-receptor positive cells. These conjugates (3 and 4), in contrast to their corresponding ligands, displayed weak binding affinities of 0.079 and 0.851 for the estrogen receptor. Conjugate 3 was consistently more cytotoxic than 4, which however showed some selectivity to estrogen receptor positive cell lines. (C) 2001 Elsevier Science Inc. All rights reserved.	en
heal.publisher	ELSEVIER SCIENCE INC	en
heal.journalName	STEROIDS	en
dc.identifier.isi	ISI:000171150600009	en
dc.identifier.volume	66	en
dc.identifier.issue	10	en
dc.identifier.spage	785	en
dc.identifier.epage	791	en