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Synthesis and biological evaluation of novel daunorubicin-estrogen conjugates

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dc.contributor.author Kasiotis, KM en
dc.contributor.author Magiatis, P en
dc.contributor.author Pratsinis, H en
dc.contributor.author Skaltsounis, AL en
dc.contributor.author Abadji, V en
dc.contributor.author Charalambous, A en
dc.contributor.author Moutsatsou, P en
dc.contributor.author Haroutounian, SA en
dc.date.accessioned 2014-03-01T01:51:20Z
dc.date.available 2014-03-01T01:51:20Z
dc.date.issued 2001 en
dc.identifier.issn 0039-128X en
dc.identifier.uri https://dspace.lib.ntua.gr/xmlui/handle/123456789/26268
dc.subject daunorubicin conjugates en
dc.subject steroidal and non-steroidal estrogen ligand en
dc.subject synthesis en
dc.subject estrogen receptor binding en
dc.subject cytotoxic activity en
dc.subject.classification Biochemistry & Molecular Biology en
dc.subject.classification Endocrinology & Metabolism en
dc.subject.other CYTO-TOXIC AGENTS en
dc.subject.other BINDING-AFFINITY en
dc.subject.other CELL-LINE en
dc.subject.other RECEPTOR en
dc.subject.other COMPLEXES en
dc.subject.other GROWTH en
dc.title Synthesis and biological evaluation of novel daunorubicin-estrogen conjugates en
heal.type journalArticle en
heal.language English en
heal.publicationDate 2001 en
heal.abstract The synthesis of two novel daunorubicin-estro-en conjugates with a steroidal and a non-steroidal ligand was undertaken in an attempt to target the cytotoxicity of anthracycline to estrogen-receptor positive cells. These conjugates (3 and 4), in contrast to their corresponding ligands, displayed weak binding affinities of 0.079 and 0.851 for the estrogen receptor. Conjugate 3 was consistently more cytotoxic than 4, which however showed some selectivity to estrogen receptor positive cell lines. (C) 2001 Elsevier Science Inc. All rights reserved. en
heal.publisher ELSEVIER SCIENCE INC en
heal.journalName STEROIDS en
dc.identifier.isi ISI:000171150600009 en
dc.identifier.volume 66 en
dc.identifier.issue 10 en
dc.identifier.spage 785 en
dc.identifier.epage 791 en


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