Computerized nuclear morphometry and quantitation of angiogenesis in thyroid neoplasms

Kavantzas, N; Tseleni-Balafouta, S; Davaris, P

dc.contributor.author	Kavantzas, N	en
dc.contributor.author	Tseleni-Balafouta, S	en
dc.contributor.author	Davaris, P	en
dc.date.accessioned	2014-03-01T01:52:02Z
dc.date.available	2014-03-01T01:52:02Z
dc.date.issued	2002	en
dc.identifier.issn	0392-9078	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/26543
dc.subject	nuclear morphometry	en
dc.subject	angiogenesis	en
dc.subject	thyroid neoplasms	en
dc.subject.classification	Oncology	en
dc.subject.other	CARCINOMA	en
dc.subject.other	LESIONS	en
dc.subject.other	INDICATOR	en
dc.subject.other	BENIGN	en
dc.title	Computerized nuclear morphometry and quantitation of angiogenesis in thyroid neoplasms	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2002	en
heal.abstract	The aim of this study was to investigate the nuclear and angiogenetic profile in different types of thyroid neoplasms and to make any possible statistical comparison between the different nuclear morphometric and angiogenetic parameters, in order to search for new diagnostic and prognostic criteria. Sixty two cases of thyroid neoplasms were classified as follows: 31 papillary carcinomas, 10 follicular neoplasms (5 adenomas and 5 carcinomas), 5 undifferentiated carcinomas, 6 Huerthle-cell carcinomas and 10 medullary carcinomas. Using an image analysis system, six nuclear morphometric and eight angiogenetic variables were measured for each case. Concerning nuclear morphometric variables, statistical differences were found mainly between undifferentiated and overall subtypes of differentiated carcinomas, as well as between follicular adenomas and carcinomas. Concerning angiogenesis variables, statistical differences were found only in the vessel's minor axis length between undifferentiated and overall subtypes of differentiated carcinomas, between MVD of follicular adenomas and carcinomas respectively, as well as between MVD of medullary carcinoma and follicular cell carcinomas generally. In conclusion nuclear morphometry and quantitation of angiogenesis could offer two additional parameters in the distinction between follicular adenomas and carcinomas. However, they cannot serve as absolute diagnostic criteria since they are only based on statistical differences. From a prognostic point of view, nuclear morphometry may have sonic relevance as far as follicular-cell neoplasms are concerned since the more aggressive anaplastic carcinomas have a distinct morphometric profile. Moreover, our study revealed differences in the angiogenetic profile between medullary and follicular cell carcinomas.	en
heal.publisher	APSIT ASSOC PROM STUD IMMUNOL TUMOR	en
heal.journalName	JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH	en
dc.identifier.isi	ISI:000176895800018	en
dc.identifier.volume	21	en
dc.identifier.issue	2	en
dc.identifier.spage	247	en
dc.identifier.epage	254	en