Thyroid gland neurofibroma in a NF1 patient

Anagnostouli, M; Piperingos, G; Yapijakis, C; Gourtzelidis, P; Balafouta, S; Zournas, C; Vassilopoulos, D; Koutras, D; Papageorgiou, C

dc.contributor.author	Anagnostouli, M	en
dc.contributor.author	Piperingos, G	en
dc.contributor.author	Yapijakis, C	en
dc.contributor.author	Gourtzelidis, P	en
dc.contributor.author	Balafouta, S	en
dc.contributor.author	Zournas, C	en
dc.contributor.author	Vassilopoulos, D	en
dc.contributor.author	Koutras, D	en
dc.contributor.author	Papageorgiou, C	en
dc.date.accessioned	2014-03-01T01:52:14Z
dc.date.available	2014-03-01T01:52:14Z
dc.date.issued	2002	en
dc.identifier.issn	0001-6314	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/26604
dc.subject	neurofibromatosis	en
dc.subject	thyroid gland	en
dc.subject	neurofibroma	en
dc.subject	neurofibromin	en
dc.subject	tumour supressor gene	en
dc.subject.classification	Clinical Neurology	en
dc.subject.other	VONRECKLINGHAUSENS DISEASE	en
dc.subject.other	TRANSFORMATION	en
dc.subject.other	CARCINOMA	en
dc.subject.other	TYPE-1	en
dc.subject.other	GENE	en
dc.title	Thyroid gland neurofibroma in a NF1 patient	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2002	en
heal.abstract	Neurofibromas are a hallmark of neurofibromatosis type 1 (NF1). They are usually benign and rarely present in the thyroid gland region. There is a suspected association between NF1 and intramedullary thyroid carcinoma and there is a well-known association between NF1 and pheochromocytoma. Here, we present a 55-year-old man with typical symptoms of NF1, whose course was complicated by a neurofibroma of the thyroid gland. His clinical spectrum of symptoms included bilateral cataract established before the age of 35 years, quadriparesis and an intrathoracic mass. The patient died because of abdominal carcinomatosis of unknown origin. The rarity of thyroid gland neurofibroma is discussed here, emphasizing the importance of early detection of these and other NF1 complications, also including the risk of malignant transformation with lethal outcome.	en
heal.publisher	BLACKWELL MUNKSGAARD	en
heal.journalName	ACTA NEUROLOGICA SCANDINAVICA	en
dc.identifier.isi	ISI:000176471200011	en
dc.identifier.volume	106	en
dc.identifier.issue	1	en
dc.identifier.spage	58	en
dc.identifier.epage	61	en