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Atherosclerosis in premenopausal women with antiphospholipid syndrome and systemic lupus erythematosus: a controlled study

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dc.contributor.author Vlachoyiannopoulos, PG en
dc.contributor.author Kanellopoulos, PG en
dc.contributor.author Ioannidis, JPA en
dc.contributor.author Tektonidou, MG en
dc.contributor.author Mastorakou, I en
dc.contributor.author Moutsopoulos, HM en
dc.date.accessioned 2014-03-01T01:53:06Z
dc.date.available 2014-03-01T01:53:06Z
dc.date.issued 2003 en
dc.identifier.issn 1462-0324 en
dc.identifier.uri https://dspace.lib.ntua.gr/xmlui/handle/123456789/26848
dc.subject antiphospholipid syndrome en
dc.subject systemic lupus erythematosus en
dc.subject atherosclerosis en
dc.subject vascular ultrasound en
dc.subject intima-media thickness en
dc.subject carotid artery en
dc.subject femoral artery en
dc.subject.classification Rheumatology en
dc.subject.other LOW-DENSITY-LIPOPROTEIN en
dc.subject.other INTIMA-MEDIA THICKNESS en
dc.subject.other C-REACTIVE PROTEIN en
dc.subject.other ANTICARDIOLIPIN ANTIBODIES en
dc.subject.other MYOCARDIAL-INFARCTION en
dc.subject.other REVISED CRITERIA en
dc.subject.other CAROTID ATHEROSCLEROSIS en
dc.subject.other CARDIOVASCULAR EVENTS en
dc.subject.other APOLIPOPROTEIN-H en
dc.subject.other RISK-FACTORS en
dc.title Atherosclerosis in premenopausal women with antiphospholipid syndrome and systemic lupus erythematosus: a controlled study en
heal.type journalArticle en
heal.language English en
heal.publicationDate 2003 en
heal.abstract Objective. To evaluate whether premenopausal women with antiphospholipid syndrome (APS) or systemic lupus erythematosus (SLE) have increased prevalence of atherosclerosis after adjustment has been made for known cardiovascular risk factors. Methods. We evaluated premenopausal women with APS in comparison with age-matched groups of patients with SLE [positive or negative for anticardiolipin (aCL) antibodies] or rheumatoid arthritis (RA), and healthy subjects. Thirty-three subjects in each group were assessed for cardiovascular risk factors, including a detailed lipid profile. Ultrasonography of carotid and femoral arteries assessed the intima-media thickness (IMT) and the presence of atherosclerotic plaque. Results. Atherosclerotic plaques were detected in 5, 2, 4, 1 and 1 subject in the five groups respectively. APS patients had significantly more affected vessels than RA patients and healthy controls (P=0.042 and P=0.016, respectively), but not compared with SLE patients. No consistent differences in IMT, traditional cardiovascular risk factors or lipid parameters were detected among the five groups. The odds for atherosclerosis independently increased 1.19-fold per year of increasing age [95% confidence interval (CI) 1.08-1.31; P=0.001), 1.019-fold per 1 mg/dl increase in low-density lipoprotein (LDL) (95% CI 1.003-1.036; P=0.020), 1.035-fold per additional 1 g of methylprednisolone equivalent cumulative corticosteroid dose (95% CI, 0.996-1.074; P=0.074), and 4.35-fold in the presence of APS or SLE (95% CI 0.75-25.2; P=0.10). Neither aCL nor anti-beta(2)GPI antibodies were associated with atherosclerosis. Conclusion. Premenopausal APS and SLE women have an increased prevalence of carotid and femoral plaque that is not accounted for by other predictors of atherosclerosis, including age, lipid parameters and cumulative steroid dose. en
heal.publisher OXFORD UNIV PRESS en
heal.journalName RHEUMATOLOGY en
dc.identifier.isi ISI:000182634400007 en
dc.identifier.volume 42 en
dc.identifier.issue 5 en
dc.identifier.spage 645 en
dc.identifier.epage 651 en


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