Atherosclerosis in premenopausal women with antiphospholipid syndrome and systemic lupus erythematosus: a controlled study

Vlachoyiannopoulos, PG; Kanellopoulos, PG; Ioannidis, JPA; Tektonidou, MG; Mastorakou, I; Moutsopoulos, HM

dc.contributor.author	Vlachoyiannopoulos, PG	en
dc.contributor.author	Kanellopoulos, PG	en
dc.contributor.author	Ioannidis, JPA	en
dc.contributor.author	Tektonidou, MG	en
dc.contributor.author	Mastorakou, I	en
dc.contributor.author	Moutsopoulos, HM	en
dc.date.accessioned	2014-03-01T01:53:06Z
dc.date.available	2014-03-01T01:53:06Z
dc.date.issued	2003	en
dc.identifier.issn	1462-0324	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/26848
dc.subject	antiphospholipid syndrome	en
dc.subject	systemic lupus erythematosus	en
dc.subject	atherosclerosis	en
dc.subject	vascular ultrasound	en
dc.subject	intima-media thickness	en
dc.subject	carotid artery	en
dc.subject	femoral artery	en
dc.subject.classification	Rheumatology	en
dc.subject.other	LOW-DENSITY-LIPOPROTEIN	en
dc.subject.other	INTIMA-MEDIA THICKNESS	en
dc.subject.other	C-REACTIVE PROTEIN	en
dc.subject.other	ANTICARDIOLIPIN ANTIBODIES	en
dc.subject.other	MYOCARDIAL-INFARCTION	en
dc.subject.other	REVISED CRITERIA	en
dc.subject.other	CAROTID ATHEROSCLEROSIS	en
dc.subject.other	CARDIOVASCULAR EVENTS	en
dc.subject.other	APOLIPOPROTEIN-H	en
dc.subject.other	RISK-FACTORS	en
dc.title	Atherosclerosis in premenopausal women with antiphospholipid syndrome and systemic lupus erythematosus: a controlled study	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2003	en
heal.abstract	Objective. To evaluate whether premenopausal women with antiphospholipid syndrome (APS) or systemic lupus erythematosus (SLE) have increased prevalence of atherosclerosis after adjustment has been made for known cardiovascular risk factors. Methods. We evaluated premenopausal women with APS in comparison with age-matched groups of patients with SLE [positive or negative for anticardiolipin (aCL) antibodies] or rheumatoid arthritis (RA), and healthy subjects. Thirty-three subjects in each group were assessed for cardiovascular risk factors, including a detailed lipid profile. Ultrasonography of carotid and femoral arteries assessed the intima-media thickness (IMT) and the presence of atherosclerotic plaque. Results. Atherosclerotic plaques were detected in 5, 2, 4, 1 and 1 subject in the five groups respectively. APS patients had significantly more affected vessels than RA patients and healthy controls (P=0.042 and P=0.016, respectively), but not compared with SLE patients. No consistent differences in IMT, traditional cardiovascular risk factors or lipid parameters were detected among the five groups. The odds for atherosclerosis independently increased 1.19-fold per year of increasing age [95% confidence interval (CI) 1.08-1.31; P=0.001), 1.019-fold per 1 mg/dl increase in low-density lipoprotein (LDL) (95% CI 1.003-1.036; P=0.020), 1.035-fold per additional 1 g of methylprednisolone equivalent cumulative corticosteroid dose (95% CI, 0.996-1.074; P=0.074), and 4.35-fold in the presence of APS or SLE (95% CI 0.75-25.2; P=0.10). Neither aCL nor anti-beta(2)GPI antibodies were associated with atherosclerosis. Conclusion. Premenopausal APS and SLE women have an increased prevalence of carotid and femoral plaque that is not accounted for by other predictors of atherosclerosis, including age, lipid parameters and cumulative steroid dose.	en
heal.publisher	OXFORD UNIV PRESS	en
heal.journalName	RHEUMATOLOGY	en
dc.identifier.isi	ISI:000182634400007	en
dc.identifier.volume	42	en
dc.identifier.issue	5	en
dc.identifier.spage	645	en
dc.identifier.epage	651	en