Synthesis of chroman analogues of lipoic acid and evaluation of their activity against reperfusion arrhythmias

Koufaki, M; Detsi, A; Theodorou, E; Kiziridi, C; Calogeropoulou, T; Vassilopoulos, A; Kourounakis, A; Rekka, E; Kourounakis, P; Gaitanaki, C; Papazafiri, P

dc.contributor.author	Koufaki, M	en
dc.contributor.author	Detsi, A	en
dc.contributor.author	Theodorou, E	en
dc.contributor.author	Kiziridi, C	en
dc.contributor.author	Calogeropoulou, T	en
dc.contributor.author	Vassilopoulos, A	en
dc.contributor.author	Kourounakis, A	en
dc.contributor.author	Rekka, E	en
dc.contributor.author	Kourounakis, P	en
dc.contributor.author	Gaitanaki, C	en
dc.contributor.author	Papazafiri, P	en
dc.date.accessioned	2014-03-01T01:53:31Z
dc.date.available	2014-03-01T01:53:31Z
dc.date.issued	2004	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/27058
dc.subject	Arrhythmia	en
dc.subject	Lipid Peroxide	en
dc.subject	lipoic acid	en
dc.title	Synthesis of chroman analogues of lipoic acid and evaluation of their activity against reperfusion arrhythmias	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.bmc.2004.07.012	en
heal.identifier.secondary	http://dx.doi.org/10.1016/j.bmc.2004.07.012	en
heal.publicationDate	2004	en
heal.abstract	Novel hybrids of lipoic acid and trolox connected through triamine spacers as well as analogues in which the lipoic acid was attached at different positions of the chroman moiety of vitamin E through an amide bond, were synthesized and exhibited strong inhibition of the microsomal lipid peroxidation. Moreover, the new molecules, at 1μM concentration, reduced reperfusion arrhythmias and MDA content	en
heal.journalName	Bioorganic & Medicinal Chemistry	en
dc.identifier.doi	10.1016/j.bmc.2004.07.012	en