Nonlinear modeling of the dynamic effects of arterial pressure and CO2 variations on cerebral blood flow in healthy humans

Mitsis, GD; Poulin, MJ; Robbins, PA; Marmarelis, VZ

dc.contributor.author	Mitsis, GD	en
dc.contributor.author	Poulin, MJ	en
dc.contributor.author	Robbins, PA	en
dc.contributor.author	Marmarelis, VZ	en
dc.date.accessioned	2014-03-01T01:53:44Z
dc.date.available	2014-03-01T01:53:44Z
dc.date.issued	2004	en
dc.identifier.issn	00189294	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/27111
dc.subject	Cerebral autoregulation	en
dc.subject	Cerebral hemodynamics	en
dc.subject	Laguerre-Volterra network	en
dc.subject	Nonlinear modeling	en
dc.subject	Nonstationary systems	en
dc.subject	Volterra kernels	en
dc.subject.other	Arterial blood pressure	en
dc.subject.other	Cerebral blood flow	en
dc.subject.other	Laguerre-Volterra network methodology	en
dc.subject.other	Blood	en
dc.subject.other	Carbon dioxide	en
dc.subject.other	Computer simulation	en
dc.subject.other	Frequencies	en
dc.subject.other	Hemodynamics	en
dc.subject.other	Mathematical models	en
dc.subject.other	Nonlinear systems	en
dc.subject.other	Blood vessels	en
dc.subject.other	carbon dioxide	en
dc.subject.other	adult	en
dc.subject.other	arterial pressure	en
dc.subject.other	article	en
dc.subject.other	autoregulation	en
dc.subject.other	brain blood flow	en
dc.subject.other	controlled study	en
dc.subject.other	dynamics	en
dc.subject.other	flow rate	en
dc.subject.other	frequency modulation	en
dc.subject.other	human	en
dc.subject.other	mathematical computing	en
dc.subject.other	mathematical model	en
dc.subject.other	Adult	en
dc.subject.other	Blood Flow Velocity	en
dc.subject.other	Blood Pressure	en
dc.subject.other	Brain	en
dc.subject.other	Carbon Dioxide	en
dc.subject.other	Cerebrovascular Circulation	en
dc.subject.other	Computer Simulation	en
dc.subject.other	Humans	en
dc.subject.other	Models, Cardiovascular	en
dc.subject.other	Nonlinear Dynamics	en
dc.subject.other	Pulmonary Gas Exchange	en
dc.subject.other	Statistics	en
dc.title	Nonlinear modeling of the dynamic effects of arterial pressure and CO2 variations on cerebral blood flow in healthy humans	en
heal.type	journalArticle	en
heal.identifier.primary	10.1109/TBME.2004.834272	en
heal.identifier.secondary	http://dx.doi.org/10.1109/TBME.2004.834272	en
heal.publicationDate	2004	en
heal.abstract	The effect of spontaneous beat-to-beat mean arterial blood pressure fluctuations and breath-to-breath end-tidal CO2 fluctuations on beat-to-beat cerebral blood flow velocity variations is studied using the Laguerre-Volterra network methodology for multiple-input nonlinear systems. The observations made from experimental measurements from ten healthy human subjects reveal that, whereas pressure fluctuations explain most of the high-frequency blood flow velocity variations (above 0.04 Hz), end-tidal CO2 fluctuations as well as nonlinear interactions between pressure and CO2 have a considerable effect in the lower frequencies (below 0.04 Hz). They also indicate that cerebral autoregulation is strongly nonlinear and dynamic (frequency-dependent). Nonlinearities are mainly active in the low-frequency range (below 0.04 Hz) and are more prominent in the dynamics of the end-tidal CO2-blood flow velocity relationship. Significant nonstationarities are also revealed by the obtained models, with greater variability evident for the effects of CO2 on blood flow velocity dynamics.	en
heal.journalName	IEEE Transactions on Biomedical Engineering	en
dc.identifier.doi	10.1109/TBME.2004.834272	en
dc.identifier.volume	51	en
dc.identifier.issue	11	en
dc.identifier.spage	1932	en
dc.identifier.epage	1943	en