Attentional facilitation of response is impaired for antisaccades but not for saccades in patients with schizophrenia: implications for cortical dysfunction

Smyrnis, N; Malogiannis, IA; Evdokimidis, I; Stefanis, NC; Theleritis, C; Vaidakis, A; Theodoropoulou, S; Stefanis, CN

dc.contributor.author	Smyrnis, N	en
dc.contributor.author	Malogiannis, IA	en
dc.contributor.author	Evdokimidis, I	en
dc.contributor.author	Stefanis, NC	en
dc.contributor.author	Theleritis, C	en
dc.contributor.author	Vaidakis, A	en
dc.contributor.author	Theodoropoulou, S	en
dc.contributor.author	Stefanis, CN	en
dc.date.accessioned	2014-03-01T01:53:52Z
dc.date.available	2014-03-01T01:53:52Z
dc.date.issued	2004	en
dc.identifier.issn	0014-4819	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/27134
dc.subject	response latency	en
dc.subject	gap effect	en
dc.subject	deficit syndrome	en
dc.subject	spatial attention	en
dc.subject	inhibition	en
dc.subject	oculomotor	en
dc.subject.classification	Neurosciences	en
dc.subject.other	POSITRON EMISSION TOMOGRAPHY	en
dc.subject.other	EYE-MOVEMENTS	en
dc.subject.other	BIOLOGICAL RELATIVES	en
dc.subject.other	NEURONAL-ACTIVITY	en
dc.subject.other	VOLUNTARY CONTROL	en
dc.subject.other	DEFICIT SYNDROME	en
dc.subject.other	FIXATION POINT	en
dc.subject.other	ANTI-SACCADES	en
dc.subject.other	PRO-SACCADES	en
dc.subject.other	FRONTAL-LOBE	en
dc.title	Attentional facilitation of response is impaired for antisaccades but not for saccades in patients with schizophrenia: implications for cortical dysfunction	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2004	en
heal.abstract	The facilitation of response known as the "gap effect" (a decrease of response latency), observed for saccades and antisaccades when attention is modulated prior to such eye movements, was studied in patients with schizophrenia and in controls. The hypothesis tested was whether patients would show a deficient attentional facilitation in response latency. Fifteen patients with schizophrenia and 17 healthy controls performed blocks of saccades and antisaccades in a "gap" condition and an "overlap" condition. Saccade and antisaccade response latencies as well as the error rate for antisaccades were measured for each subject. A similar gap effect (decrease in latency for the gap compared to the overlap condition) was present in the saccade task for patients and controls. In contrast the gap effect in the antisaccade task was absent in 50% of patients compared to none of the controls. This finding was interpreted as indicative of deficient preprocessing in antisaccade-specific cortical areas in schizophrenia (such as the prefrontal cortex), while visually guided saccade processing remained intact. Our results, in addition to many other recent findings, could lead to specific hypotheses on cortical dysfunction in schizophrenia.	en
heal.publisher	SPRINGER	en
heal.journalName	EXPERIMENTAL BRAIN RESEARCH	en
dc.identifier.isi	ISI:000224613500005	en
dc.identifier.volume	159	en
dc.identifier.issue	1	en
dc.identifier.spage	47	en
dc.identifier.epage	54	en