Autoimmune manifestations in human myelodysplasia: a positive correlation with interferon regulatory factor-1 (IRF-1) expression

Giannouli, S; Tzoanopoulos, D; Ritis, K; Kartalis, G; Moutsopoulos, HM; Voulgarelis, M

dc.contributor.author	Giannouli, S	en
dc.contributor.author	Tzoanopoulos, D	en
dc.contributor.author	Ritis, K	en
dc.contributor.author	Kartalis, G	en
dc.contributor.author	Moutsopoulos, HM	en
dc.contributor.author	Voulgarelis, M	en
dc.date.accessioned	2014-03-01T01:53:53Z
dc.date.available	2014-03-01T01:53:53Z
dc.date.issued	2004	en
dc.identifier.issn	0003-4967	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/27135
dc.subject.classification	Rheumatology	en
dc.subject.other	CLASSIFICATION	en
dc.subject.other	LEUKEMIA	en
dc.subject.other	MICE	en
dc.title	Autoimmune manifestations in human myelodysplasia: a positive correlation with interferon regulatory factor-1 (IRF-1) expression	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2004	en
heal.abstract	Background: Patients with myelodysplasia may have autoimmune manifestations ( AIM). Interferon regulatory factor-1 (IRF-1) is a transcription factor involved in interferon signalling, leukaemogenesis, and the development of the immune system. Objectives: To determine whether IRF-1 is implicated in the pathophysiology of AIM in myelodysplasia. Methods: 14 patients with myelodysplasia were studied, seven with AIM and seven without. Five patients with vasculitis and seven normal subjects served as controls. The expression of IRF-1 was studied in bone marrow mononuclear cells taken from patients and controls, using a relative quantitative reverse transcriptase polymerase chain reaction. Results: A 10-fold reduction in full length IRF-1 mRNA was detected in the myelodysplasia patients without AIM compared with the normal controls. In contrast, the group with AIM had increased IRF-1 transcripts, to a level almost equal to that observed in patients with vasculitis and normal controls. Conclusions: Myelodysplasia patients without IRF-1 expression had a decreased incidence of AIM. Thus the absence of IRF-1 transcription factor appears to protect against the development of autoimmunity in myelodysplasia.	en
heal.publisher	B M J PUBLISHING GROUP	en
heal.journalName	ANNALS OF THE RHEUMATIC DISEASES	en
dc.identifier.isi	ISI:000220813600019	en
dc.identifier.volume	63	en
dc.identifier.issue	5	en
dc.identifier.spage	578	en
dc.identifier.epage	582	en