Circulating angiogenic factors during periovulation and the luteal phase of normal menstrual cycles

Malamitsi-Puchner, A; Sarandakou, A; Tziotis, J; Stavreus-Evers, A; Tzonou, A; Landgren, BM

dc.contributor.author	Malamitsi-Puchner, A	en
dc.contributor.author	Sarandakou, A	en
dc.contributor.author	Tziotis, J	en
dc.contributor.author	Stavreus-Evers, A	en
dc.contributor.author	Tzonou, A	en
dc.contributor.author	Landgren, BM	en
dc.date.accessioned	2014-03-01T01:53:55Z
dc.date.available	2014-03-01T01:53:55Z
dc.date.issued	2004	en
dc.identifier.issn	0015-0282	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/27137
dc.subject	menstruation	en
dc.subject	angiogenesis	en
dc.subject	vascular endothelial growth factor	en
dc.subject	basic fibroblast growth factor	en
dc.subject	angiogenin	en
dc.subject	periovulation	en
dc.subject.classification	Obstetrics & Gynecology	en
dc.subject.classification	Reproductive Biology	en
dc.subject.other	ENDOTHELIAL GROWTH-FACTOR	en
dc.subject.other	VASCULAR-PERMEABILITY FACTOR	en
dc.subject.other	FACTOR VEGF	en
dc.subject.other	EXPRESSION	en
dc.subject.other	CELLS	en
dc.subject.other	ENDOMETRIUM	en
dc.subject.other	PRIMATE	en
dc.subject.other	PROTEIN	en
dc.title	Circulating angiogenic factors during periovulation and the luteal phase of normal menstrual cycles	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2004	en
heal.abstract	Objective: To measure serial serum concentrations of the angiogenic factors vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and angiogenin (ANG) in the periovulatory and secretory phase of normal menstrual cycles in healthy women and to determine their peaks, which might reflect the stage of their critical angiogenic action. Design: Prospective study. Setting: University departments of obstetrics and gynecology. Participant(s): Thirty-three healthy Swedish women with regular menstrual cycles. Intervention(s): Serial blood samples were collected from each woman. Luteinizing hormone surge was identified by testing morning urine. Main Outcome Measure(s): Circulating levels of VEGF, bFGF, and ANG. Result(s): Circulating peak concentrations were determined for VEGF on day 0 and 9 after ovulation, for bFGF on day 1 before ovulation and day 9 after ovulation, and for ANG on day 3 after ovulation. Conclusion(s): Circulating VEGF increased in a stage-dependent cyclic fashion. Basic FGF peaked during the late proliferative and mid secretory phase. Circulating ANG showed increased expression around the early secretory phase of the cycle.	en
heal.publisher	ELSEVIER SCIENCE INC	en
heal.journalName	FERTILITY AND STERILITY	en
dc.identifier.isi	ISI:000221439400025	en
dc.identifier.volume	81	en
dc.identifier.issue	5	en
dc.identifier.spage	1322	en
dc.identifier.epage	1327	en