Novel short-step synthesis of functionalized gamma-phenyl-beta-hydroxybutenoates and their cyclization to 4-hydroxycoumarins via the N-hydroxybenzotriazole methodology

Athanasellis, G; Melagraki, G; Chatzidakis, H; Afantitis, A; Detsi, A; Igglessi-Markopoulou, O; Markopoulos, J

dc.contributor.author	Athanasellis, G	en
dc.contributor.author	Melagraki, G	en
dc.contributor.author	Chatzidakis, H	en
dc.contributor.author	Afantitis, A	en
dc.contributor.author	Detsi, A	en
dc.contributor.author	Igglessi-Markopoulou, O	en
dc.contributor.author	Markopoulos, J	en
dc.date.accessioned	2014-03-01T01:54:01Z
dc.date.available	2014-03-01T01:54:01Z
dc.date.issued	2004	en
dc.identifier.issn	0039-7881	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/27164
dc.subject	coumarins	en
dc.subject	N-hydroxybenzotriazole	en
dc.subject	natural products	en
dc.subject	acylations	en
dc.subject	NMR spectroscopy	en
dc.subject	heterocycles	en
dc.subject.classification	Chemistry, Organic	en
dc.subject.other	ALPHA-HYDROXY ACIDS	en
dc.subject.other	ONE-POT SYNTHESIS	en
dc.subject.other	PECHMANN REACTION	en
dc.subject.other	DERIVATIVES	en
dc.subject.other	COUMARINS	en
dc.subject.other	1-HYDROXYBENZOTRIAZOLE	en
dc.subject.other	CONDENSATION	en
dc.subject.other	COMMUNIS	en
dc.subject.other	ACCESS	en
dc.subject.other	ROUTE	en
dc.title	Novel short-step synthesis of functionalized gamma-phenyl-beta-hydroxybutenoates and their cyclization to 4-hydroxycoumarins via the N-hydroxybenzotriazole methodology	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2004	en
heal.abstract	A novel method for the synthesis of functionalized 3-substituted 4-hydroxycoumarins is reported. C-Acylation compounds were derived from the reaction of the N-hydroxybenzotriazole ester of the functionalized acetyl salicylic acids and a variety of active methylene compounds and cyclized to the title compounds. The synthesis is simple and the compounds are produced in yields varying from 39 to 80%. The structure of the newly prepared C-acylation compounds was thoroughly studied through NMR spectroscopy for the first time in the literature.	en
heal.publisher	GEORG THIEME VERLAG KG	en
heal.journalName	SYNTHESIS-STUTTGART	en
dc.identifier.isi	ISI:000223208100012	en
dc.identifier.issue	11	en
dc.identifier.spage	1775	en
dc.identifier.epage	1782	en