Novel Short-Step Synthesis of Functionalized γ-Phenyl-β-hydroxybutenoates and Their Cyclization to 4-Hydroxycoumarins via the N-Hydroxybenzotriazole Methodology

Athanasellis, G; Melagraki, G; Chatzidakis, H; Afantitis, A; Detsi, A; Igglessi-Markopoulou, O; Markopoulos, J

dc.contributor.author	Athanasellis, G	en
dc.contributor.author	Melagraki, G	en
dc.contributor.author	Chatzidakis, H	en
dc.contributor.author	Afantitis, A	en
dc.contributor.author	Detsi, A	en
dc.contributor.author	Igglessi-Markopoulou, O	en
dc.contributor.author	Markopoulos, J	en
dc.date.accessioned	2014-03-01T01:54:18Z
dc.date.available	2014-03-01T01:54:18Z
dc.date.issued	2005	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/27302
dc.subject	Density Functional	en
dc.subject	Nitrogen	en
dc.title	Novel Short-Step Synthesis of Functionalized γ-Phenyl-β-hydroxybutenoates and Their Cyclization to 4-Hydroxycoumarins via the N-Hydroxybenzotriazole Methodology	en
heal.type	journalArticle	en
heal.identifier.primary	DOI: 10.1002/ejoc.200300422	en
heal.identifier.secondary	http://dx.doi.org/DOI: 10.1002/ejoc.200300422	en
heal.publicationDate	2005	en
heal.abstract	The synthesis of novel N-urethane-protected γ-methylamino- β-oxo esters and their use as precursors for the preparation of N-methyltetramic acids is described. The presence of the bulky urethane protecting group on the nitrogen atom gives rise to rotational isomers detectable in the NMR spectra of the compounds, along with the keto/enol tautomerism. The mechanism of the cyclisation reaction of γ-amino-β-oxo esters	en
heal.journalName	Cheminform	en
dc.identifier.doi	DOI: 10.1002/ejoc.200300422	en