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Synthesis, binding studies and in vivo biological evaluation of novel non-peptide antihypertensive analogues

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dc.contributor.author Mavromoustakos, T en
dc.contributor.author Moutevelis-Minakakis, P en
dc.contributor.author Kokotos, C en
dc.contributor.author Kontogianni, P en
dc.contributor.author Politi, A en
dc.contributor.author Zoumpoulakis, P en
dc.contributor.author Findlay, J en
dc.contributor.author Cox, A en
dc.contributor.author Balmforth, A en
dc.contributor.author Zoga, A en
dc.contributor.author Iliodromitis, E en
dc.date.accessioned 2014-03-01T01:55:17Z
dc.date.available 2014-03-01T01:55:17Z
dc.date.issued 2006 en
dc.identifier.uri https://dspace.lib.ntua.gr/xmlui/handle/123456789/27665
dc.subject Angiotensin Ii en
dc.subject Binding Affinity en
dc.subject High Blood Pressure en
dc.subject Hydrogen Bond en
dc.subject Amino Acid en
dc.title Synthesis, binding studies and in vivo biological evaluation of novel non-peptide antihypertensive analogues en
heal.type journalArticle en
heal.identifier.primary 10.1016/j.bmc.2006.02.044 en
heal.identifier.secondary http://dx.doi.org/10.1016/j.bmc.2006.02.044 en
heal.publicationDate 2006 en
heal.abstract AT1 antagonists (SARTANs) constitute the last generation of drugs for the treatment of hypertension, designed and synthesized to mimic the C-terminal segment of the vasoconstrictive hormone angiotensin II (AngII). They exert their action by blocking the binding of AngII on the AT1 receptor. Up to date eight AT1 antagonists have been approved for the regulation of high blood pressure. Although en
heal.journalName Bioorganic & Medicinal Chemistry en
dc.identifier.doi 10.1016/j.bmc.2006.02.044 en


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