Synthesis, binding studies and in vivo biological evaluation of novel non-peptide antihypertensive analogues

Mavromoustakos, T; Moutevelis-Minakakis, P; Kokotos, C; Kontogianni, P; Politi, A; Zoumpoulakis, P; Findlay, J; Cox, A; Balmforth, A; Zoga, A; Iliodromitis, E

dc.contributor.author	Mavromoustakos, T	en
dc.contributor.author	Moutevelis-Minakakis, P	en
dc.contributor.author	Kokotos, C	en
dc.contributor.author	Kontogianni, P	en
dc.contributor.author	Politi, A	en
dc.contributor.author	Zoumpoulakis, P	en
dc.contributor.author	Findlay, J	en
dc.contributor.author	Cox, A	en
dc.contributor.author	Balmforth, A	en
dc.contributor.author	Zoga, A	en
dc.contributor.author	Iliodromitis, E	en
dc.date.accessioned	2014-03-01T01:55:17Z
dc.date.available	2014-03-01T01:55:17Z
dc.date.issued	2006	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/27665
dc.subject	Angiotensin Ii	en
dc.subject	Binding Affinity	en
dc.subject	High Blood Pressure	en
dc.subject	Hydrogen Bond	en
dc.subject	Amino Acid	en
dc.title	Synthesis, binding studies and in vivo biological evaluation of novel non-peptide antihypertensive analogues	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.bmc.2006.02.044	en
heal.identifier.secondary	http://dx.doi.org/10.1016/j.bmc.2006.02.044	en
heal.publicationDate	2006	en
heal.abstract	AT1 antagonists (SARTANs) constitute the last generation of drugs for the treatment of hypertension, designed and synthesized to mimic the C-terminal segment of the vasoconstrictive hormone angiotensin II (AngII). They exert their action by blocking the binding of AngII on the AT1 receptor. Up to date eight AT1 antagonists have been approved for the regulation of high blood pressure. Although	en
heal.journalName	Bioorganic & Medicinal Chemistry	en
dc.identifier.doi	10.1016/j.bmc.2006.02.044	en