Aberrant alternative splicing of interferon regulatory factor-1 (IRF-1) in myelodysplastic hematopoietic progenitor cells

Maratheftis, CI; Bolaraki, PE; Giannouli, S; Kapsogeorgou, EK; Moutsopoulos, HM; Voulgarelis, M

dc.contributor.author	Maratheftis, CI	en
dc.contributor.author	Bolaraki, PE	en
dc.contributor.author	Giannouli, S	en
dc.contributor.author	Kapsogeorgou, EK	en
dc.contributor.author	Moutsopoulos, HM	en
dc.contributor.author	Voulgarelis, M	en
dc.date.accessioned	2014-03-01T01:55:30Z
dc.date.available	2014-03-01T01:55:30Z
dc.date.issued	2006	en
dc.identifier.issn	0145-2126	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/27769
dc.subject	myelodysplastic syndrome	en
dc.subject	IRF-1	en
dc.subject	alternative splicing	en
dc.subject	hematopoiesis	en
dc.subject.classification	Oncology	en
dc.subject.classification	Hematology	en
dc.subject.other	ACUTE MYELOID-LEUKEMIA	en
dc.subject.other	TRANSCRIPTION FACTOR IRF-1	en
dc.subject.other	SEQUENCE BINDING-PROTEIN	en
dc.subject.other	NITRIC-OXIDE SYNTHASE	en
dc.subject.other	GENE	en
dc.subject.other	EXPRESSION	en
dc.subject.other	MUTATIONS	en
dc.subject.other	DIFFERENTIATION	en
dc.subject.other	ABNORMALITIES	en
dc.subject.other	INDUCTION	en
dc.title	Aberrant alternative splicing of interferon regulatory factor-1 (IRF-1) in myelodysplastic hematopoietic progenitor cells	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2006	en
heal.abstract	Interferon regulatory factor-1 (IRF-1) mRNA expression was examined in specific cell populations (BMMC, CD34(+) and CD71(+)) derived from 45 MDS patients and 20 controls. All the MDS cell populations, presented an identical IRF-1 mRNA expression pattern, characterized by the absence of full-length IRF-1 mRNA and presence of multiple alternative transcripts. The most common deletions involved exons 2 and 3. Two novel truncated IRF-1 protein forms were detected in MDS BMMC. IRF-1-induced iNOS mRNA expression was exclusively detected in BMMC having full-length transcript. The expression of IRF-1 truncated mRNA and protein forms might be a critical event in the development of MDS. (c) 2006 Elsevier Ltd. All rights reserved.	en
heal.publisher	PERGAMON-ELSEVIER SCIENCE LTD	en
heal.journalName	LEUKEMIA RESEARCH	en
dc.identifier.isi	ISI:000239620500020	en
dc.identifier.volume	30	en
dc.identifier.issue	9	en
dc.identifier.spage	1177	en
dc.identifier.epage	1186	en