Aberrant alternative splicing of interferon regulatory factor-1 (IRF-1) in myelodysplastic hematopoietic progenitor cells

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dc.contributor.author Maratheftis, CI en
dc.contributor.author Bolaraki, PE en
dc.contributor.author Giannouli, S en
dc.contributor.author Kapsogeorgou, EK en
dc.contributor.author Moutsopoulos, HM en
dc.contributor.author Voulgarelis, M en
dc.date.accessioned 2014-03-01T01:55:30Z
dc.date.available 2014-03-01T01:55:30Z
dc.date.issued 2006 en
dc.identifier.issn 0145-2126 en
dc.identifier.uri http://hdl.handle.net/123456789/27769
dc.subject myelodysplastic syndrome en
dc.subject IRF-1 en
dc.subject alternative splicing en
dc.subject hematopoiesis en
dc.subject.classification Oncology en
dc.subject.classification Hematology en
dc.subject.other ACUTE MYELOID-LEUKEMIA en
dc.subject.other TRANSCRIPTION FACTOR IRF-1 en
dc.subject.other SEQUENCE BINDING-PROTEIN en
dc.subject.other NITRIC-OXIDE SYNTHASE en
dc.subject.other GENE en
dc.subject.other EXPRESSION en
dc.subject.other MUTATIONS en
dc.subject.other DIFFERENTIATION en
dc.subject.other ABNORMALITIES en
dc.subject.other INDUCTION en
dc.title Aberrant alternative splicing of interferon regulatory factor-1 (IRF-1) in myelodysplastic hematopoietic progenitor cells en
heal.type journalArticle en
heal.language English en
heal.publicationDate 2006 en
heal.abstract Interferon regulatory factor-1 (IRF-1) mRNA expression was examined in specific cell populations (BMMC, CD34(+) and CD71(+)) derived from 45 MDS patients and 20 controls. All the MDS cell populations, presented an identical IRF-1 mRNA expression pattern, characterized by the absence of full-length IRF-1 mRNA and presence of multiple alternative transcripts. The most common deletions involved exons 2 and 3. Two novel truncated IRF-1 protein forms were detected in MDS BMMC. IRF-1-induced iNOS mRNA expression was exclusively detected in BMMC having full-length transcript. The expression of IRF-1 truncated mRNA and protein forms might be a critical event in the development of MDS. (c) 2006 Elsevier Ltd. All rights reserved. en
heal.journalName LEUKEMIA RESEARCH en
dc.identifier.isi ISI:000239620500020 en
dc.identifier.volume 30 en
dc.identifier.issue 9 en
dc.identifier.spage 1177 en
dc.identifier.epage 1186 en

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