Add-on lamotrigine treatment and plasma glutamate levels in epilepsy: Relation to treatment response

Paraskevas, GP; Triantafyllou, NI; Kapaki, E; Limpitaki, G; Petropoulou, O; Vassilopoulos, D

dc.contributor.author	Paraskevas, GP	en
dc.contributor.author	Triantafyllou, NI	en
dc.contributor.author	Kapaki, E	en
dc.contributor.author	Limpitaki, G	en
dc.contributor.author	Petropoulou, O	en
dc.contributor.author	Vassilopoulos, D	en
dc.date.accessioned	2014-03-01T01:55:30Z
dc.date.available	2014-03-01T01:55:30Z
dc.date.issued	2006	en
dc.identifier.issn	0920-1211	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/27770
dc.subject	lamotrigine	en
dc.subject	epilepsy	en
dc.subject	glutamate	en
dc.subject	excitatory neurotransmitters	en
dc.subject.classification	Clinical Neurology	en
dc.subject.other	AMYOTROPHIC-LATERAL-SCLEROSIS	en
dc.subject.other	SERUM AMINO-ACIDS	en
dc.subject.other	ANTIEPILEPTIC DRUG	en
dc.subject.other	CEREBROSPINAL-FLUID	en
dc.subject.other	METABOLISM	en
dc.subject.other	POLYTHERAPY	en
dc.subject.other	ASPARTATE	en
dc.title	Add-on lamotrigine treatment and plasma glutamate levels in epilepsy: Relation to treatment response	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2006	en
heal.abstract	We investigated the effects of add-on lamotrigine treatment on plasma glutamate (Glu) levels, in 29 epileptic patients. Plasma Glu levels were determined by high-performance liquid chromatography at baseline and at 1 and 3 months post-treatment. In patients with a seizure reduction of >= 66% a decrease of Glu at month 1 was noted, followed by return to baseline levels at month 3. In the remaining patients a gradual increase of Glu was noted throughout the 3 months of the study. The above findings indicate that an excellent clinical response to add-on lamotrigine may be characterized by a statistically significant, yet transient decrease of plasma Glu levels, while increasing Glu levels may accompany a response that is moderate at best. The combination of lamotrigine with valproate was more frequent in patients with excellent clinical response and tended to result in glutamate decrease. (c) 2006 Elsevier B.V All rights reserved.	en
heal.publisher	ELSEVIER SCIENCE BV	en
heal.journalName	EPILEPSY RESEARCH	en
dc.identifier.isi	ISI:000240371600012	en
dc.identifier.volume	70	en
dc.identifier.issue	2-3	en
dc.identifier.spage	184	en
dc.identifier.epage	189	en