Pseudohyperkalemia in serum: the phenomenon and its clinical magnitude

Sevastos, N; Theodossiades, G; Efstathiou, S; Papatheodoridis, GV; Manesis, E; Archimandritis, AJ

dc.contributor.author	Sevastos, N	en
dc.contributor.author	Theodossiades, G	en
dc.contributor.author	Efstathiou, S	en
dc.contributor.author	Papatheodoridis, GV	en
dc.contributor.author	Manesis, E	en
dc.contributor.author	Archimandritis, AJ	en
dc.date.accessioned	2014-03-01T01:55:35Z
dc.date.available	2014-03-01T01:55:35Z
dc.date.issued	2006	en
dc.identifier.issn	0022-2143	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/27801
dc.subject.classification	Medical Laboratory Technology	en
dc.subject.classification	Medicine, General & Internal	en
dc.subject.classification	Medicine, Research & Experimental	en
dc.subject.other	THROMBOCYTOSIS	en
dc.subject.other	POTASSIUM	en
dc.subject.other	PLATELETS	en
dc.subject.other	RELEASE	en
dc.title	Pseudohyperkalemia in serum: the phenomenon and its clinical magnitude	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2006	en
heal.abstract	We investigated in detail the difference between serum and plasma potassium levels in patients with several conditions associated with pseudohyperkalemia. In total, 435 patients with either thrombocytoses, erythrocytoses, leucocytoses, or a mixed-type disorder and 30 healthy controls were included. In each case, the index Dk (serum potassium minus plasma potassium) and the index Dk100 (Dk x 100,000/platelets), which indicates the Dk value that corresponds to platelets of 100,000/mm(3) were estimated. Median Dk was significantly higher in the groups with platelet, erythrocyte, or mixed-type disorders than in the controls (P = 0.001). Among these groups, Dk values were significantly higher in patients with thrombocytosis or mixed-type disorders compared with those with erythrocytosis (P < 0.001, for both). Furthermore, no significant difference was observed in Dk values between controls and patients with white blood cell disorders (P = 0.74). Dk values did not exceed 2.61 mmol/L, whereas Dk100 values were inversely related to platelet counts (r = - 0.351, P < 0.01). In conclusion, pseudohyperkalemia is mainly present in patients with thrombocytosis or mixed-type disorders, probably as a result of the degranulation of platelets, which offers a potassium load to the surrounding plasma at the time of clot formation in vitro. However, the degree of pseudohyperkalemia does not increase proportionally with the increase of platelet counts, which may be associated with transfer of part of potassium load from the plasma back into red and white blood cells.	en
heal.publisher	MOSBY, INC	en
heal.journalName	JOURNAL OF LABORATORY AND CLINICAL MEDICINE	en
dc.identifier.isi	ISI:000236094100006	en
dc.identifier.volume	147	en
dc.identifier.issue	3	en
dc.identifier.spage	139	en
dc.identifier.epage	144	en