Association study of cholesterol-related genes in Alzheimer's disease

Wollmer, MA; Sleegers, K; Ingelsson, M; Zekanowski, C; Brouwers, N; Maruszak, A; Brunner, F; Huynh, KD; Kilander, L; Brundin, RM; Hedlund, M; Giedraitis, V; Glaser, A; Engelborghs, S; De Deyn, PP; Kapaki, E; Tsolaki, M; Daniilidou, M; Molyva, D; Paraskevas, GP; Thal, DR; Barcikowska, M; Kuznicki, J; Lannfelt, L; Van Broeckhoven, C; Nitsch, RM; Hock, C; Papassotiropoulos, A

dc.contributor.author	Wollmer, MA	en
dc.contributor.author	Sleegers, K	en
dc.contributor.author	Ingelsson, M	en
dc.contributor.author	Zekanowski, C	en
dc.contributor.author	Brouwers, N	en
dc.contributor.author	Maruszak, A	en
dc.contributor.author	Brunner, F	en
dc.contributor.author	Huynh, KD	en
dc.contributor.author	Kilander, L	en
dc.contributor.author	Brundin, RM	en
dc.contributor.author	Hedlund, M	en
dc.contributor.author	Giedraitis, V	en
dc.contributor.author	Glaser, A	en
dc.contributor.author	Engelborghs, S	en
dc.contributor.author	De Deyn, PP	en
dc.contributor.author	Kapaki, E	en
dc.contributor.author	Tsolaki, M	en
dc.contributor.author	Daniilidou, M	en
dc.contributor.author	Molyva, D	en
dc.contributor.author	Paraskevas, GP	en
dc.contributor.author	Thal, DR	en
dc.contributor.author	Barcikowska, M	en
dc.contributor.author	Kuznicki, J	en
dc.contributor.author	Lannfelt, L	en
dc.contributor.author	Van Broeckhoven, C	en
dc.contributor.author	Nitsch, RM	en
dc.contributor.author	Hock, C	en
dc.contributor.author	Papassotiropoulos, A	en
dc.date.accessioned	2014-03-01T01:56:28Z
dc.date.available	2014-03-01T01:56:28Z
dc.date.issued	2007	en
dc.identifier.issn	1364-6745	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/28106
dc.subject	HMGCS2	en
dc.subject	FDPS	en
dc.subject	NPC2	en
dc.subject	ABCG1	en
dc.subject	polymorphism	en
dc.subject.classification	Genetics & Heredity	en
dc.subject.classification	Clinical Neurology	en
dc.subject.other	LATE-ONSET	en
dc.subject.other	APOLIPOPROTEIN-E	en
dc.subject.other	RISK-FACTOR	en
dc.subject.other	GENOME SCREEN	en
dc.subject.other	AMYLOID LOAD	en
dc.subject.other	METABOLISM	en
dc.subject.other	CHROMOSOME-10	en
dc.subject.other	LINKAGE	en
dc.subject.other	ALLELE	en
dc.subject.other	SUSCEPTIBILITY	en
dc.title	Association study of cholesterol-related genes in Alzheimer's disease	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2007	en
heal.abstract	Alzheimer's disease (AD) is a genetically complex disorder, and several genes related to cholesterol metabolism have been reported to contribute to AD risk. To identify further AD susceptibility genes, we have screened genes that map to chromosomal regions with high logarithm of the odds scores for AD in full genome scans and are related to cholesterol metabolism. In a European screening sample of 115 sporadic AD patients and 191 healthy control subjects, we analyzed single nucleotide polymorphisms in 28 cholesterol-related genes for association with AD. The genes HMGCS2, FDPS, RAFTLIN, ACAD8, NPC2, and ABCG1 were associated with AD at a significance level of P <= 0.05 in this sample. Replication trials in five independent European samples detected associations of variants within HMGCS2, FDPS, NPC2, or ABCG1 with AD in some samples (P=0.05 to P=0.005). We did not identify a marker that was significantly associated with AD in the pooled sample (n=2864). Stratification of this sample revealed an APOE-dependent association of HMGCS2 with AD (P=0.004). We conclude that genetic variants investigated in this study may be associated with a moderate modification of the risk for AD in some samples.	en
heal.publisher	SPRINGER	en
heal.journalName	NEUROGENETICS	en
dc.identifier.isi	ISI:000247971400003	en
dc.identifier.volume	8	en
dc.identifier.issue	3	en
dc.identifier.spage	179	en
dc.identifier.epage	188	en