Design and synthesis of novel quinolinone-3-aminoamides and their alpha-lipoic acid adducts as antioxidant and antiiflammatory agents

Detsi, A; Bouloumbasi, D; Prousis, KC; Koufaki, M; Athanasellis, G; Melagraki, G; Afantitis, A; Igglessi-Markopoulou, O; Kontogiorgis, C; Hadjipavlou-Litina, DJ

dc.contributor.author	Detsi, A	en
dc.contributor.author	Bouloumbasi, D	en
dc.contributor.author	Prousis, KC	en
dc.contributor.author	Koufaki, M	en
dc.contributor.author	Athanasellis, G	en
dc.contributor.author	Melagraki, G	en
dc.contributor.author	Afantitis, A	en
dc.contributor.author	Igglessi-Markopoulou, O	en
dc.contributor.author	Kontogiorgis, C	en
dc.contributor.author	Hadjipavlou-Litina, DJ	en
dc.date.accessioned	2014-03-01T01:56:28Z
dc.date.available	2014-03-01T01:56:28Z
dc.date.issued	2007	en
dc.identifier.issn	0022-2623	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/28111
dc.subject.classification	Chemistry, Medicinal	en
dc.subject.other	ACTIVE METHYLENE-COMPOUNDS	en
dc.subject.other	PPAR-GAMMA AGONISTS	en
dc.subject.other	ANTIINFLAMMATORY ACTIVITY	en
dc.subject.other	5-LIPOXYGENASE INHIBITORS	en
dc.subject.other	REPERFUSION ARRHYTHMIAS	en
dc.subject.other	BIOLOGICAL EVALUATION	en
dc.subject.other	LIPID-PEROXIDATION	en
dc.subject.other	DUAL INHIBITORS	en
dc.subject.other	STEP SYNTHESIS	en
dc.subject.other	ACETIC-ACID	en
dc.title	Design and synthesis of novel quinolinone-3-aminoamides and their alpha-lipoic acid adducts as antioxidant and antiiflammatory agents	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2007	en
heal.abstract	A series of N-substituted-quinolinone-3-aminoamides and their hybrids containing the alpha-lipoic acid functionality were designed and synthesized as potential bifunctional agents combining antioxidant and anti-inflammatory activity. The new compounds were evaluated for their antioxidant activity and for their ability to inhibit in vitro lipoxygenase as well as for their anti-inflammatory activity in vivo. In general, the derivatives were found to be potent antioxidant or anti-inflammatory agents. The results are discussed in terms of structure-activity relationships and an attempt is made to define the structural features required for activity.	en
heal.publisher	AMER CHEMICAL SOC	en
heal.journalName	JOURNAL OF MEDICINAL CHEMISTRY	en
dc.identifier.isi	ISI:000246341000021	en
dc.identifier.volume	50	en
dc.identifier.issue	10	en
dc.identifier.spage	2450	en
dc.identifier.epage	2458	en