Hypophysitis superimposed on a non-functioning pituitary adenoma: Diagnostic clinical, endocrine, and radiologic features

Ballian, N; Chrisoulidou, A; Nomikos, P; Samara, C; Kontogeorgos, G; Kaltsas, GA

dc.contributor.author	Ballian, N	en
dc.contributor.author	Chrisoulidou, A	en
dc.contributor.author	Nomikos, P	en
dc.contributor.author	Samara, C	en
dc.contributor.author	Kontogeorgos, G	en
dc.contributor.author	Kaltsas, GA	en
dc.date.accessioned	2014-03-01T01:56:29Z
dc.date.available	2014-03-01T01:56:29Z
dc.date.issued	2007	en
dc.identifier.issn	0391-4097	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/28124
dc.subject	hypophysitis	en
dc.subject	pituitary	en
dc.subject	adenoma	en
dc.subject.classification	Endocrinology & Metabolism	en
dc.subject.other	LYMPHOCYTIC HYPOPHYSITIS	en
dc.subject.other	ANTIPITUITARY ANTIBODIES	en
dc.subject.other	AUTOIMMUNE HYPOPHYSITIS	en
dc.subject.other	ALPHA-ENOLASE	en
dc.subject.other	ADENOHYPOPHYSITIS	en
dc.subject.other	EXPERIENCE	en
dc.subject.other	MANAGEMENT	en
dc.subject.other	DEFICIENCY	en
dc.subject.other	DISEASE	en
dc.subject.other	TUMORS	en
dc.title	Hypophysitis superimposed on a non-functioning pituitary adenoma: Diagnostic clinical, endocrine, and radiologic features	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2007	en
heal.abstract	Pituitary adenomas are common neo-plasms requiring medical and/or surgical treatment when associated with hormonal hypersecretion. Treatment of non-functioning pituitary adenomas is necessary when symptoms of mass effect or hormonal deficits occur. However, therapeutic options, including surgical resection and/or radiotherapy, can be associated with significant complications. Hence, it is important to consider disorders that could present in a similar manner to the pituitary adenomas, for the which surgery is not the indicated therapeutic approach. We describe herein a 38-yr-old woman who presented with pituitary lesion that considered to be a non-functioning pituitary lesion that was considered to be a non-functioning pituitary adenoma. Due to lack of hormonal deficits and/or compression of adjacent structures, we opted for conservation management and follow-up with consecutive magnetic resonance imaging. Fifteen months after initial diagnosis, considerable enlargement of the lesion was noted, extending mainly superiorly and indenting the potic chiasm. Repeated endocrine investigation revealed partial anterior pituitary insufficiency. The patient underwent trans-sphenoidal resection of the pituitary lesion; histology revealed a null cell pituitary adenoma and lymphocytic hypophysitis (LYH) of the non-neoplastic adenophypophysial gland. Post-operatively, complete anterior and partial posterior pituitary insuffiency developed. This case illustrates the effects of new-onset LYH in a patient with a pre-existing non-functioning pituatary adenoma. Being aware of this rare possibility is important, as enlargement of the pituitary lesion may not be caused by expansion of the pre-existing tumor, but by the onset of LYH of the non-neoplastic pituitary tissue.	en
heal.publisher	EDITRICE KURTIS S R L	en
heal.journalName	JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION	en
dc.identifier.isi	ISI:000250675600010	en
dc.identifier.volume	30	en
dc.identifier.issue	8	en
dc.identifier.spage	677	en
dc.identifier.epage	683	en