Mononuclear copper(II) complexes with quinolones and nitrogen-donor heterocyclic ligands: Synthesis, characterization, biological activity and interaction with DNA

Efthimiadou, EK; Katsaros, N; Karaliota, A; Psomas, G

dc.contributor.author	Efthimiadou, EK	en
dc.contributor.author	Katsaros, N	en
dc.contributor.author	Karaliota, A	en
dc.contributor.author	Psomas, G	en
dc.date.accessioned	2014-03-01T01:56:30Z
dc.date.available	2014-03-01T01:56:30Z
dc.date.issued	2007	en
dc.identifier.issn	0020-1693	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/28134
dc.subject	quinolones	en
dc.subject	N-propyl-norfloxacin	en
dc.subject	pipemidic acid	en
dc.subject	copper(II) complexes	en
dc.subject	interaction with calf-thymus DNA	en
dc.subject	MIC	en
dc.subject.classification	Chemistry, Inorganic & Nuclear	en
dc.subject.other	RAY STRUCTURAL CHARACTERIZATION	en
dc.subject.other	URINARY-TRACT-INFECTIONS	en
dc.subject.other	N-N DONORS	en
dc.subject.other	CRYSTAL-STRUCTURE	en
dc.subject.other	METAL-IONS	en
dc.subject.other	FAMILY-MEMBER	en
dc.subject.other	ANTIBACTERIAL AGENTS	en
dc.subject.other	CINOXACIN COMPLEXES	en
dc.subject.other	HERBICIDE COMPLEXES	en
dc.subject.other	CIRCULAR-DICHROISM	en
dc.title	Mononuclear copper(II) complexes with quinolones and nitrogen-donor heterocyclic ligands: Synthesis, characterization, biological activity and interaction with DNA	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2007	en
heal.abstract	The neutral mononuclear copper(II) complexes with the quinolone antibacterial drugs, pipemidic acid and N-propyl-norfloxacin, in the presence or absence of nitrogen-donor heterocyclic ligands, 2,2'-bipyridine, 1,10-phenanthroline or 2,2'-dipyridylamine, have been prepared and characterized spectroscopically. The interaction of copper(II) with the deprotonated quinolone ligand leads to the formation of the neutral mononuclear complexes of the type [Cu(quinolone)(2)(H2O)] (1)-(2) while the presence of the N-donor ligand leads to the formation of the neutral mononuclear complexes of the type [Cu(quinolone)(N-donor)Cl] (3)-(8). In all the complexes, copper(II) is pentacoordinate having a distorted square pyramidal geometry. The electron paramagnetic resonance spectra of 1 and 2 are typical of mononuclear Cu(II) complexes, while for the mixed-ligands complexes 3-8 a mixture of dimeric and monomeric species is indicated. The interaction of the complexes with calf-thymus DNA has been investigated with diverse spectroscopic techniques and has shown that the complexes can be bound to calf-thymus DNA by the intercalative mode. The antimicrobial activity of the complexes has been tested on three different microorganisms. All the complexes show an increased biological activity in comparison to the corresponding free quinolone ligand. (C) 2007 Elsevier B.V. All rights reserved.	en
heal.publisher	ELSEVIER SCIENCE SA	en
heal.journalName	INORGANICA CHIMICA ACTA	en
dc.identifier.isi	ISI:000253488300004	en
dc.identifier.volume	360	en
dc.identifier.issue	15	en
dc.identifier.spage	4093	en
dc.identifier.epage	4102	en