Neurochemical profile of elderly alcoholic patients with cognitive decline compared with patients with other dementias

Kapaki, E; Paraskevas, GP; Theotoka, I; Liappas, I

dc.contributor.author	Kapaki, E	en
dc.contributor.author	Paraskevas, GP	en
dc.contributor.author	Theotoka, I	en
dc.contributor.author	Liappas, I	en
dc.date.accessioned	2014-03-01T01:56:31Z
dc.date.available	2014-03-01T01:56:31Z
dc.date.issued	2007	en
dc.identifier.issn	1565-012X	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/28136
dc.subject	chronic alcohol dependence	en
dc.subject	alcohol related dementia	en
dc.subject	Alzheimer's disease	en
dc.subject	tau protein	en
dc.subject	beta-amyloid (1-42)	en
dc.subject	cerebrospinal fluid	en
dc.subject.classification	Public, Environmental & Occupational Health	en
dc.subject.other	CEREBROSPINAL-FLUID TAU	en
dc.subject.other	BETA-AMYLOID 1-42	en
dc.subject.other	ALZHEIMERS-DISEASE	en
dc.subject.other	CSF-TAU	en
dc.subject.other	DIAGNOSTIC-CRITERIA	en
dc.subject.other	VASCULAR DEMENTIA	en
dc.subject.other	LEWY BODIES	en
dc.subject.other	PROTEIN	en
dc.subject.other	ETHANOL	en
dc.subject.other	RISK	en
dc.title	Neurochemical profile of elderly alcoholic patients with cognitive decline compared with patients with other dementias	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2007	en
heal.abstract	Alcoholism may result in impaired cognition and dementia. The increased risk of dementia in older individuals interferes with the differential diagnosis, especially when an elderly patient with a long history of alcohol abuse is the case. The aim of the present study was to evaluate the diagnostic value of the putative cerebrospinal fluid (CSF) biomarkers tau, beta-amyloid 1-42 (A beta 42) and their ratio in differentiating alcohol related dementia (ARD) from others of vascular or degenerative aetiology. Double-sandwich ELISAs (Innotest htau antigen and beta-Amyloid (142), Innogenetics) were used to quantify the above markers in a total of 151 patients and 82 controls. Patient groups comprised: 24 ARD, 17 vascular dementia, I I dementia with Lewy bodies, 23 frontotemporal dementia and 76 Alzheimer's disease (AD) patients. Tau protein succeessfully differentiated ARD from AD with 88% specificity and 86% sensitivity. A beta 42 alone had a specificity of 86% and a sensitivity of 70%, while tau/A beta 42 ratio was better than tau alone with corresponding values 100% and 91% respectively. For the discrimination of ARD from other dementias the diagnostic value of the above markers is substantially lower. In conclusion, the combined use of CSF tau and A beta 42 seems to be a useful tool in the differential diagnosis of ARD from AD, while in other primary dementias only a positive result may be useful.	en
heal.publisher	FREUND PUBLISHING HOUSE LTD	en
heal.journalName	INTERNATIONAL JOURNAL ON DISABILITY AND HUMAN DEVELOPMENT	en
dc.identifier.isi	ISI:000254391400012	en
dc.identifier.volume	6	en
dc.identifier.issue	2	en
dc.identifier.spage	215	en
dc.identifier.epage	223	en