Antiphospholipid syndrome (APS) nephropathy in catastrophic, primary, and systemic lupus erythematosus-related APS

Tektonidou, MG; Sotsiou, F; Moutsopoulos, HM

dc.contributor.author	Tektonidou, MG	en
dc.contributor.author	Sotsiou, F	en
dc.contributor.author	Moutsopoulos, HM	en
dc.date.accessioned	2014-03-01T01:57:18Z
dc.date.available	2014-03-01T01:57:18Z
dc.date.issued	2008	en
dc.identifier.issn	0315-162X	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/28396
dc.subject	antiphospholipid syndrome	en
dc.subject	kidney biopsy	en
dc.subject	renal	en
dc.subject.classification	Rheumatology	en
dc.subject.other	INTERNATIONAL CONSENSUS STATEMENT	en
dc.subject.other	CLASSIFICATION CRITERIA	en
dc.subject.other	ANTIBODIES	en
dc.subject.other	UPDATE	en
dc.title	Antiphospholipid syndrome (APS) nephropathy in catastrophic, primary, and systemic lupus erythematosus-related APS	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2008	en
heal.abstract	Objective. Renal involvement in antiphospholipid syndrome (APS) has been poorly recognized. A renal small-vessel Vasculopathy defined as APS nephropathy, has recently been observed in small series of patients with primary APS (PAPS) and systemic lupus erythematosus (SLE)-APS. We examined the renal histologic, clinical, and laboratory characteristics of different groups of patients with APS including Catastrophic APS (CAPS). Methods. Our study included all CAPS (n = 6), PAPS (n = 8), and SLE-APS (n = 23) patients Willi biopsy-proven renal involvement Who were referred to Our departments. The kidney biopsy specimens were retrospectively examined by the same renal pathologist. APS nephropathy was diagnosed as previously described, Demographic. clinical, and laboratory data were recorded. Results. All patients With CAPS had acute and chronic renal Vascular lesions compatible with diagnosis of APS nephropathy. Thrombotic microangiopathy (TMA). the acute lesion, was observed in all CAPS patient,,. Fibrous intimal hyperplasia of interlobular arteries (FIH) and focal cortical atrophy (FCA) Were the most common chronic Vascular lesions, occurring ill 4 of 6 (66.7%) all(] 3 of 6 (50%) patients with CAPS, respectively. TMA was detected in 3 of 8 (37.5%) patients with PAPS and in 8 of 23 (35%) patients Willi SLE-APS. while FIH and FCA were found with similar frequencies in till 3 groups. Hypertension. proteinuria. hematuria, and renal insufficiency were the most common renal mainfestations of all APS groups. Conclusion. Acute and chronic APS nephropathy lesions were detected in all 3 APS groups. Acute lesions were more prominent ill CAPS, while chronic lesions were found with similar frequencies all groups. Hypertension. proteinuria, hematuria. and renal insufficiency were the most common renal mainifestations of all APS groups.	en
heal.publisher	J RHEUMATOL PUBL CO	en
heal.journalName	JOURNAL OF RHEUMATOLOGY	en
dc.identifier.isi	ISI:000259908900013	en
dc.identifier.volume	35	en
dc.identifier.issue	10	en
dc.identifier.spage	1983	en
dc.identifier.epage	1988	en