Association of demographic, clinical and treatment variables with quality of life of patients with epilepsy in Greece

Piperidou, C; Karlovasitou, A; Triantafyllou, N; Dimitrakoudi, E; Terzoudi, A; Mavraki, E; Trypsianis, G; Vadikolias, K; Heliopoulos, I; Vassilopoulos, D; Balogiannis, S

dc.contributor.author	Piperidou, C	en
dc.contributor.author	Karlovasitou, A	en
dc.contributor.author	Triantafyllou, N	en
dc.contributor.author	Dimitrakoudi, E	en
dc.contributor.author	Terzoudi, A	en
dc.contributor.author	Mavraki, E	en
dc.contributor.author	Trypsianis, G	en
dc.contributor.author	Vadikolias, K	en
dc.contributor.author	Heliopoulos, I	en
dc.contributor.author	Vassilopoulos, D	en
dc.contributor.author	Balogiannis, S	en
dc.date.accessioned	2014-03-01T01:57:19Z
dc.date.available	2014-03-01T01:57:19Z
dc.date.issued	2008	en
dc.identifier.issn	0962-9343	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/28399
dc.subject	epilepsy	en
dc.subject	quality of life	en
dc.subject	seizures frequency	en
dc.subject	age	en
dc.subject	type of seizures	en
dc.subject	AEDs	en
dc.subject	use of benzodiazepines	en
dc.subject.classification	Health Care Sciences & Services	en
dc.subject.classification	Public, Environmental & Occupational Health	en
dc.subject.classification	Nursing	en
dc.subject.other	LAMOTRIGINE MONOTHERAPY	en
dc.subject.other	RESISTANT EPILEPSY	en
dc.subject.other	INVENTORY QOLIE-31	en
dc.subject.other	SEIZURE FREQUENCY	en
dc.subject.other	CLOBAZAM	en
dc.subject.other	IMPROVEMENT	en
dc.subject.other	DEPRESSION	en
dc.subject.other	PEOPLE	en
dc.subject.other	IMPACT	en
dc.subject.other	DRUG	en
dc.title	Association of demographic, clinical and treatment variables with quality of life of patients with epilepsy in Greece	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2008	en
heal.abstract	Purpose The aim was to study the influence of patients' age, frequency and type of seizures, disease duration, number of AEDs and use of benzodiazepines on the quality of life of patients with epilepsy. Patients and methods We consecutively identified 223 patients with epilepsy who attended the epilepsy outpatient clinics at three university hospitals in Greece. Quality of life was evaluated by QOLIE-31. One-way analysis was used to assess the association of the studied factors and QOLIE-31 subscales. After checking for co-linearity, we performed multivariate stepwise linear regression analysis with all the variables that on univariate analysis showed a statistically significant effect on each subscale of QOLIE-31 to explore which of the studied factors affect independently on QOLIE-31 scores. Results Of a total of 223 patients, 118 (52.95%) were men; mean age was 35.18 +/- 13.22; mean duration of the disease was 13 years; 58 (26%) patients had generalized seizures, 93 (41.7%) had PS, and 72 (32.3%) of the patients had PsG; 85 (38.1%) were on polytherapy and 38 (17%) were taking benzodiazepines. Independent factors affecting QoL were: seizure frequency (Overall QoL P = 0.0001, Seizure worry and Emotional well-being P < 0.0001, Energy/fatigue and Social functioning P = 0.01); duration of the disease (Overall QoL and Energy/fatigue P = 0.01, Seizure worry P = 0.008, Cognitive functioning P < 0.0001); polytherapy only for the Emotional well-being P < 0.0001; and use of benzodiazepines (Overall QoL, Energy/fatigue, Social functioning P = 0.002, Cognitive functioning P < 0.0001). Conclusion Our findings suggest that QoL in epileptic patients might be affected, in addition to the other established factors (high frequency of seizures and polytherapy), by the daily use of benzodiazepines as adjunctive therapy. Change of medical strategy concerning this medication may lead to improving the QoL of these patients.	en
heal.publisher	SPRINGER	en
heal.journalName	QUALITY OF LIFE RESEARCH	en
dc.identifier.isi	ISI:000258657900003	en
dc.identifier.volume	17	en
dc.identifier.issue	7	en
dc.identifier.spage	987	en
dc.identifier.epage	996	en