Copper(II) complexes with sparfloxacin and nitrogen-donor heterocyclic ligands: Structure-activity relationship

Efthimiadou, EK; Katsarou, ME; Karaliota, A; Psomas, G

dc.contributor.author	Efthimiadou, EK	en
dc.contributor.author	Katsarou, ME	en
dc.contributor.author	Karaliota, A	en
dc.contributor.author	Psomas, G	en
dc.date.accessioned	2014-03-01T01:57:20Z
dc.date.available	2014-03-01T01:57:20Z
dc.date.issued	2008	en
dc.identifier.issn	0162-0134	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/28404
dc.subject	quinolones	en
dc.subject	sparfloxacin	en
dc.subject	copper(II) complexes	en
dc.subject	molecular modeling	en
dc.subject	interaction with calf-thymus DNA	en
dc.subject	MIC	en
dc.subject.classification	Biochemistry & Molecular Biology	en
dc.subject.classification	Chemistry, Inorganic & Nuclear	en
dc.subject.other	FAMILY-MEMBER CIPROFLOXACIN	en
dc.subject.other	MONONUCLEAR METAL-COMPLEXES	en
dc.subject.other	N-PROPYL-NORFLOXACIN	en
dc.subject.other	CRYSTAL-STRUCTURE	en
dc.subject.other	BIOLOGICAL-ACTIVITY	en
dc.subject.other	QUINOLONE FAMILY	en
dc.subject.other	ANTIBACTERIAL ACTIVITY	en
dc.subject.other	OXOLINIC ACID	en
dc.subject.other	CINOXACIN COMPLEXES	en
dc.subject.other	HERBICIDE COMPLEXES	en
dc.title	Copper(II) complexes with sparfloxacin and nitrogen-donor heterocyclic ligands: Structure-activity relationship	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2008	en
heal.abstract	Three novel neutral mononuclear copper(II) complexes of the third-generation quinolone antibacterial drug sparfloxacin in the presence of a nitrogen donor heterocyclic ligand 2,2'-bipyri dine, 1,10-phenanthroline or 2,2'-dipyridylamine have been prepared and characterized physicochemically and spectroscopically. The resultant complexes are of the type Cu(sparfloxacinato)(N-donor)Cl. Copper(II) is pentacoordinate having a distorted square pyramidal geometry. Molecular modeling calculations have been performed in order to propose the lowest energy model structure of the complexes. The interaction of the complexes with calf-thymus DNA has been investigated with diverse spectroscopic techniques and has shown that the complexes can bind to calf-thymus DNA by the intercalative mode. The antimicrobial activity of the complexes has been tested on three different microorganisms. The Cu(sparfloxacinato)(N-donor)Cl complexes are among the most active ones against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus, when compared to the other corresponding copper-quinolone complexes studied by our group and their antimicrobial activity is increased in the order bipyam < bipy = phen. We have also shown that two of the Cu(sparfloxacinato)(N-donor)Cl complexes have decreased the viability of human leukemia cells HL-60 in a time-dependent manner. (C) 2007 Elsevier Inc. All rights reserved.	en
heal.publisher	ELSEVIER SCIENCE INC	en
heal.journalName	JOURNAL OF INORGANIC BIOCHEMISTRY	en
dc.identifier.isi	ISI:000255131500033	en
dc.identifier.volume	102	en
dc.identifier.issue	4	en
dc.identifier.spage	910	en
dc.identifier.epage	920	en