Prevalence and longterm course of primary biliary cirrhosis in primary Sjogrens syndrome

Hatzis, GS; Fragoulis, GE; Karatzaferis, A; Delladetsima, I; Barbatis, C; Moutsopoulos, HM

dc.contributor.author	Hatzis, GS	en
dc.contributor.author	Fragoulis, GE	en
dc.contributor.author	Karatzaferis, A	en
dc.contributor.author	Delladetsima, I	en
dc.contributor.author	Barbatis, C	en
dc.contributor.author	Moutsopoulos, HM	en
dc.date.accessioned	2014-03-01T01:57:35Z
dc.date.available	2014-03-01T01:57:35Z
dc.date.issued	2008	en
dc.identifier.issn	0315-162X	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/28442
dc.subject	Sjogren's syndrome	en
dc.subject	primary biliary cirrhosis	en
dc.subject	antimitochondrial autoantibodies	en
dc.subject	chronic liver disease	en
dc.subject.classification	Rheumatology	en
dc.subject.other	AUTOIMMUNE RHEUMATIC-DISEASES	en
dc.subject.other	SICCA SYNDROME	en
dc.subject.other	LIVER INVOLVEMENT	en
dc.subject.other	AUTOANTIBODIES	en
dc.subject.other	EPITHELITIS	en
dc.subject.other	ANTIBODIES	en
dc.subject.other	ARTHRITIS	en
dc.subject.other	FEATURES	en
dc.title	Prevalence and longterm course of primary biliary cirrhosis in primary Sjogrens syndrome	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2008	en
heal.abstract	Objective. To study the prevalence of primary biliary cirrhosis (PBC) and its progression in patients with primary Sjogren's syndrome (SS). Methods. We investigated 410 patients with primary SS, without history of liver disease. For the presence of PBC based oil it retrospective review of clinical, biochemical, immunologic, and histologic data. Results. Thirty-six (8.8%) patients had cholestatic liver biochemistry. Of them, 21 (5.1%) had positive antimitochondrial autoantibodies (AMA) detected by indirect immunofluorescence, while 15 were AMA-negative. Tell of the 21 ANIA-positive patients and 7 of the 15 AMA-negative patients were further investigated) with liver biopsy. the result of which was compatible with PBC in all but one (AMA-negative) Patient. Overall, 27 (6.6%) patients had definite (n = 10). probable (it = 11). or AMA-negative (n = 6) PBC. Pathologically, most PBC lesions were stage 1. Five patients had a second liver biopsy. with no significant histological deterioration. Conclusion. PBC is a rather Uncommon development in Patients with primary SS. The disease appears to be pathologically mild, with a propensity for slow progression. as assessed clinically, biochemically, and histologically.	en
heal.publisher	J RHEUMATOL PUBL CO	en
heal.journalName	JOURNAL OF RHEUMATOLOGY	en
dc.identifier.isi	ISI:000259908900018	en
dc.identifier.volume	35	en
dc.identifier.issue	10	en
dc.identifier.spage	2012	en
dc.identifier.epage	2016	en