Application of 3D QSAR CoMFA/CoMSIA and in silico docking studies on novel renin inhibitors against cardiovascular diseases

Politi, A; Durdagi, S; Moutevelis-Minakakis, P; Kokotos, G; Papadopoulos, M; Mavromoustakos, T

dc.contributor.author	Politi, A	en
dc.contributor.author	Durdagi, S	en
dc.contributor.author	Moutevelis-Minakakis, P	en
dc.contributor.author	Kokotos, G	en
dc.contributor.author	Papadopoulos, M	en
dc.contributor.author	Mavromoustakos, T	en
dc.date.accessioned	2014-03-01T01:57:42Z
dc.date.available	2014-03-01T01:57:42Z
dc.date.issued	2009	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/28483
dc.subject	Cardiovascular Disease	en
dc.subject	Correlation Coefficient	en
dc.subject	in silico	en
dc.subject	Structure Activity Relationship	en
dc.title	Application of 3D QSAR CoMFA/CoMSIA and in silico docking studies on novel renin inhibitors against cardiovascular diseases	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.ejmech.2009.03.040	en
heal.identifier.secondary	http://dx.doi.org/10.1016/j.ejmech.2009.03.040	en
heal.publicationDate	2009	en
heal.abstract	For the first time, a set of renin inhibitors were subjected to the 3D QSAR/CoMFA and CoMSIA studies. The utility of renin inhibitors in the treatment of cardiovascular diseases has not been fully explored yet. At the moment, aliskiren is the first and only existing renin inhibitor in the drug market. The performed 3D QSAR/CoMFA and CoMSIA in combination with	en
heal.journalName	European Journal of Medicinal Chemistry	en
dc.identifier.doi	10.1016/j.ejmech.2009.03.040	en