New nonlinear multivariable model shows the relationship between central corneal thickness and HRTII topographic parameters in glaucoma patients

Kourkoutas, D; Georgopoulos, G; Maragos, A; Apostolakis, I; Tsekouras, G; Karanasiou, IS; Papaconstantinou, D; Iliakis, E; Moschos, M

dc.contributor.author	Kourkoutas, D	en
dc.contributor.author	Georgopoulos, G	en
dc.contributor.author	Maragos, A	en
dc.contributor.author	Apostolakis, I	en
dc.contributor.author	Tsekouras, G	en
dc.contributor.author	Karanasiou, IS	en
dc.contributor.author	Papaconstantinou, D	en
dc.contributor.author	Iliakis, E	en
dc.contributor.author	Moschos, M	en
dc.date.accessioned	2014-03-01T01:58:46Z
dc.date.available	2014-03-01T01:58:46Z
dc.date.issued	2009	en
dc.identifier.issn	11775467	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/28720
dc.relation.uri	http://www.scopus.com/inward/record.url?eid=2-s2.0-77953384873&partnerID=40&md5=4e399f636caeca51ac422300ee313cf6	en
dc.subject	Central corneal thickness	en
dc.subject	Glaucoma	en
dc.subject	HRT	en
dc.subject	Optic nerve head	en
dc.subject.other	adult	en
dc.subject.other	aged	en
dc.subject.other	article	en
dc.subject.other	clinical article	en
dc.subject.other	cornea thickness	en
dc.subject.other	female	en
dc.subject.other	glaucoma	en
dc.subject.other	human	en
dc.subject.other	intraocular pressure	en
dc.subject.other	male	en
dc.subject.other	multivariate analysis	en
dc.subject.other	optic nerve	en
dc.subject.other	regression analysis	en
dc.subject.other	tomography	en
dc.title	New nonlinear multivariable model shows the relationship between central corneal thickness and HRTII topographic parameters in glaucoma patients	en
heal.type	journalArticle	en
heal.publicationDate	2009	en
heal.abstract	Purpose: In this paper a new nonlinear multivariable regression method is presented in order to investigate the relationship between the central corneal thickness (CCT) and the Heidelberg Retina Tomograph (HRTII) optic nerve head (ONH) topographic measurements, in patients with established glaucoma. Methods: Forty nine eyes of 49 patients with glaucoma were included in this study. Inclusion criteria were patients with (a) HRT II ONH imaging of good quality (SD < 30 μm), (b) reliable Humphrey visual field tests (30-2 program), and (c) bilateral CCT measurements with ultrasonic contact pachymetry. Patients were classified as glaucomatous based on visual field and/or ONH damage. The relationship between CCT and topographic parameters was analyzed by using the new nonlinear multivariable regression model. Results: In the entire group, CCT was 549.78 ± 33.08 μm (range: 484-636 μm); intraocular pressure (IOP) was 16.4 ± 2.67 mmHg (range: 11-23 mmHg); MD was -3.80 ± 4.97 dB (range: 4.04 - [-20.4] dB); refraction was -0.78 ± 2.46 D (range: -6.0 D to +3.0 D). The new nonlinear multivariable regression model we used indicated that CCT was significantly related (R2 = 0.227, p < 0.01) with rim volume nasally and type of diagnosis. Conclusions: By using the new nonlinear multivariable regression model, in patients with established glaucoma, our data showed that there is a statistically significant correlation between CCT and HRTII ONH structural measurements, in glaucoma patients. © 2009 Kourkoutas et al, publisher and licensee Dove Medical Press Ltd.	en
heal.journalName	Clinical Ophthalmology	en
dc.identifier.volume	3	en
dc.identifier.issue	1	en
dc.identifier.spage	313	en
dc.identifier.epage	323	en