Circulating interleukin-10 and interleukin-12 in Parkinson's disease

Rentzos, M; Nikolaou, C; Andreadou, E; Paraskevas, GP; Rombos, A; Zoga, M; Tsoutsou, A; Boufidou, F; Kapaki, E; Vassilopoulos, D

dc.contributor.author	Rentzos, M	en
dc.contributor.author	Nikolaou, C	en
dc.contributor.author	Andreadou, E	en
dc.contributor.author	Paraskevas, GP	en
dc.contributor.author	Rombos, A	en
dc.contributor.author	Zoga, M	en
dc.contributor.author	Tsoutsou, A	en
dc.contributor.author	Boufidou, F	en
dc.contributor.author	Kapaki, E	en
dc.contributor.author	Vassilopoulos, D	en
dc.date.accessioned	2014-03-01T01:58:51Z
dc.date.available	2014-03-01T01:58:51Z
dc.date.issued	2009	en
dc.identifier.issn	0001-6314	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/28757
dc.subject	IL-12	en
dc.subject	IL-10	en
dc.subject	Serum	en
dc.subject	ELISA	en
dc.subject	Parkinson's disease	en
dc.subject	immunological disturbances	en
dc.subject	l-dopa treatment	en
dc.subject.classification	Clinical Neurology	en
dc.subject.other	TUMOR-NECROSIS-FACTOR	en
dc.subject.other	FACTOR-ALPHA	en
dc.subject.other	ALZHEIMERS-DISEASE	en
dc.subject.other	CYTOKINE PRODUCTION	en
dc.subject.other	MULTIPLE-SCLEROSIS	en
dc.subject.other	MICROGLIAL CELLS	en
dc.subject.other	IL-10	en
dc.subject.other	BRAIN	en
dc.subject.other	LIPOPOLYSACCHARIDE	en
dc.subject.other	ISCHEMIA	en
dc.title	Circulating interleukin-10 and interleukin-12 in Parkinson's disease	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2009	en
heal.abstract	Interleukin (IL)-12 is a heterodimeric cytokine produced by activated blood monocytes, macrophages and glial cells. It enhances differentiation and proliferation of T cells and increases production of proinflammatory cytokines. IL-10 is a pleiotropic cytokine produced by both lymphocytes and mononuclear phagocytes including microglia. Recent studies demonstrated the neuroprotective effect of IL-10. There is little information about the involvement of IL-12 or IL-10 in the pathophysiology of Parkinson's disease (PD). The objective of our study was to assess the role of IL-12 as a potential marker of immune reactions in patients with PD and to investigate whether IL-10, an immunosuppressive cytokine, may have a neuroprotective effect in the pathogenesis of PD. We measured using immunoassay serum IL-12 and IL-10 levels in 41 patients with PD in comparison with serum levels in 19 healthy subjects (controls) age and sex matched. IL-12 and IL-10 levels were tested for correlation with sex, age, disease duration, Hoehn and Yahr stage and the UPDRS III score. The PD group presented with significantly increased IL-10 levels when compared with the control group (P = 0.02). The increase observed was not affected by the treatment status. A strong and significant correlation between IL-10 and IL-12 levels was observed in patients with PD (R-S = 0.7, P < 0.000001). Our findings suggest that IL-10 may be involved in the pathogenetic mechanisms of PD. The elevation of IL-10 and the significant correlation between IL-10 and IL-12, a proinflammatory cytokine, may suggest that immunological disturbances and neuroprotective mechanisms are involved in patients with PD.	en
heal.publisher	WILEY-BLACKWELL PUBLISHING, INC	en
heal.journalName	ACTA NEUROLOGICA SCANDINAVICA	en
dc.identifier.isi	ISI:000265069900007	en
dc.identifier.volume	119	en
dc.identifier.issue	5	en
dc.identifier.spage	332	en
dc.identifier.epage	337	en