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Circulating interleukin-10 and interleukin-12 in Parkinson's disease

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dc.contributor.author Rentzos, M en
dc.contributor.author Nikolaou, C en
dc.contributor.author Andreadou, E en
dc.contributor.author Paraskevas, GP en
dc.contributor.author Rombos, A en
dc.contributor.author Zoga, M en
dc.contributor.author Tsoutsou, A en
dc.contributor.author Boufidou, F en
dc.contributor.author Kapaki, E en
dc.contributor.author Vassilopoulos, D en
dc.date.accessioned 2014-03-01T01:58:51Z
dc.date.available 2014-03-01T01:58:51Z
dc.date.issued 2009 en
dc.identifier.issn 0001-6314 en
dc.identifier.uri https://dspace.lib.ntua.gr/xmlui/handle/123456789/28757
dc.subject IL-12 en
dc.subject IL-10 en
dc.subject Serum en
dc.subject ELISA en
dc.subject Parkinson's disease en
dc.subject immunological disturbances en
dc.subject l-dopa treatment en
dc.subject.classification Clinical Neurology en
dc.subject.other TUMOR-NECROSIS-FACTOR en
dc.subject.other FACTOR-ALPHA en
dc.subject.other ALZHEIMERS-DISEASE en
dc.subject.other CYTOKINE PRODUCTION en
dc.subject.other MULTIPLE-SCLEROSIS en
dc.subject.other MICROGLIAL CELLS en
dc.subject.other IL-10 en
dc.subject.other BRAIN en
dc.subject.other LIPOPOLYSACCHARIDE en
dc.subject.other ISCHEMIA en
dc.title Circulating interleukin-10 and interleukin-12 in Parkinson's disease en
heal.type journalArticle en
heal.language English en
heal.publicationDate 2009 en
heal.abstract Interleukin (IL)-12 is a heterodimeric cytokine produced by activated blood monocytes, macrophages and glial cells. It enhances differentiation and proliferation of T cells and increases production of proinflammatory cytokines. IL-10 is a pleiotropic cytokine produced by both lymphocytes and mononuclear phagocytes including microglia. Recent studies demonstrated the neuroprotective effect of IL-10. There is little information about the involvement of IL-12 or IL-10 in the pathophysiology of Parkinson's disease (PD). The objective of our study was to assess the role of IL-12 as a potential marker of immune reactions in patients with PD and to investigate whether IL-10, an immunosuppressive cytokine, may have a neuroprotective effect in the pathogenesis of PD. We measured using immunoassay serum IL-12 and IL-10 levels in 41 patients with PD in comparison with serum levels in 19 healthy subjects (controls) age and sex matched. IL-12 and IL-10 levels were tested for correlation with sex, age, disease duration, Hoehn and Yahr stage and the UPDRS III score. The PD group presented with significantly increased IL-10 levels when compared with the control group (P = 0.02). The increase observed was not affected by the treatment status. A strong and significant correlation between IL-10 and IL-12 levels was observed in patients with PD (R-S = 0.7, P < 0.000001). Our findings suggest that IL-10 may be involved in the pathogenetic mechanisms of PD. The elevation of IL-10 and the significant correlation between IL-10 and IL-12, a proinflammatory cytokine, may suggest that immunological disturbances and neuroprotective mechanisms are involved in patients with PD. en
heal.publisher WILEY-BLACKWELL PUBLISHING, INC en
heal.journalName ACTA NEUROLOGICA SCANDINAVICA en
dc.identifier.isi ISI:000265069900007 en
dc.identifier.volume 119 en
dc.identifier.issue 5 en
dc.identifier.spage 332 en
dc.identifier.epage 337 en


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