Frequency and Causes of Early-onset Dementia in a Tertiary Referral Center in Athens

Papageorgiou, SG; Kontaxis, T; Bonakis, A; Kalfakis, N; Vassilopoulos, D

dc.contributor.author	Papageorgiou, SG	en
dc.contributor.author	Kontaxis, T	en
dc.contributor.author	Bonakis, A	en
dc.contributor.author	Kalfakis, N	en
dc.contributor.author	Vassilopoulos, D	en
dc.date.accessioned	2014-03-01T01:58:53Z
dc.date.available	2014-03-01T01:58:53Z
dc.date.issued	2009	en
dc.identifier.issn	0893-0341	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/28771
dc.subject	dementia	en
dc.subject	early-onset dementia	en
dc.subject	presenile dementia	en
dc.subject	young onset dementia	en
dc.subject.classification	Clinical Neurology	en
dc.subject.classification	Pathology	en
dc.subject.other	FRONTOTEMPORAL LOBAR DEGENERATION	en
dc.subject.other	INTERNATIONAL WORKSHOP	en
dc.subject.other	DIAGNOSTIC-CRITERIA	en
dc.subject.other	ALZHEIMERS-DISEASE	en
dc.subject.other	CONSECUTIVE PATIENTS	en
dc.subject.other	PRESENILE-DEMENTIA	en
dc.subject.other	VASCULAR DEMENTIA	en
dc.subject.other	PREVALENCE	en
dc.subject.other	AGE	en
dc.subject.other	INVENTORY	en
dc.title	Frequency and Causes of Early-onset Dementia in a Tertiary Referral Center in Athens	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2009	en
heal.abstract	Objective: To investigate the frequency and causes of early-onset dementia (EOD) in consecutive patients in it highly specialized dementia referral center, focusing oil unusual cases, particularly with early and/or rapid onset, in Athens, Greece. Methods: Patients referred for dementia diagnosis according to specific referral criteria during it 3 years period. We examined the distribution of patients diagnosis and differences in sex, education, dementia severity, cognitive function, and the duration of disease (from onset to referral) between the EOD ( < 65 y) and the late-onset dementia (LOD) groups. Results: From a total of 260 consecutive demented patients, there were 114 EOD patients or 44% of all demented patients. No significant differences were observed between the EOD and LOD groups in cognitive or behavioral measures. However, the duration from onset to consultation was significantly longer in the EOD group. Also, in the EOD group, the rates of patients with Alzheimer disease and Parkinson disease dementia were relatively low and the rate of patients with frontotemporal lobar degeneration was relatively high and the proportion of secondary dementias was high. Conclusions: We conclude that EOD patients are more likely to be seen in specialized settings. The underlying diseases are considerably different in EOD compared with LOD. Secondary causes are often found in patients with EOD. Patients with EOD had all unexpectedly longer time-to-diagnosis than patients with LOD. This argues for a need of better education about the clinical presentation of dementia in the young and middle aged.	en
heal.publisher	LIPPINCOTT WILLIAMS & WILKINS	en
heal.journalName	ALZHEIMER DISEASE & ASSOCIATED DISORDERS	en
dc.identifier.isi	ISI:000272403700008	en
dc.identifier.volume	23	en
dc.identifier.issue	4	en
dc.identifier.spage	347	en
dc.identifier.epage	351	en