Rapidly Progressive Dementia Causes Found in a Greek Tertiary Referral Center in Athens

Papageorgiou, SG; Kontaxis, T; Bonakis, A; Karahalios, G; Kalfakis, N; Vassilopoulos, D

dc.contributor.author	Papageorgiou, SG	en
dc.contributor.author	Kontaxis, T	en
dc.contributor.author	Bonakis, A	en
dc.contributor.author	Karahalios, G	en
dc.contributor.author	Kalfakis, N	en
dc.contributor.author	Vassilopoulos, D	en
dc.date.accessioned	2014-03-01T01:58:57Z
dc.date.available	2014-03-01T01:58:57Z
dc.date.issued	2009	en
dc.identifier.issn	0893-0341	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/28791
dc.subject	dementia	en
dc.subject	rapidly progressive dementias	en
dc.subject	spongiform encephalopathy	en
dc.subject	secondary dementias	en
dc.subject	treatable dementias	en
dc.subject.classification	Clinical Neurology	en
dc.subject.classification	Pathology	en
dc.subject.other	CREUTZFELDT-JAKOB-DISEASE	en
dc.subject.other	MULTIPLE SYSTEM ATROPHY	en
dc.subject.other	MOTOR-NEURON DISEASE	en
dc.subject.other	ALZHEIMERS-DISEASE	en
dc.subject.other	INTERNATIONAL WORKSHOP	en
dc.subject.other	DIAGNOSTIC-CRITERIA	en
dc.subject.other	CLINICAL-DIAGNOSIS	en
dc.subject.other	FRONTOTEMPORAL DEMENTIA	en
dc.subject.other	CEREBROSPINAL-FLUID	en
dc.subject.other	VASCULAR DEMENTIA	en
dc.title	Rapidly Progressive Dementia Causes Found in a Greek Tertiary Referral Center in Athens	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2009	en
heal.abstract	Dementia is generally considered as rapidly progressive [rapidly progressive dementia (RPD)], in cases with overt cognitive impairment, established within months. Data about the relative frequency of underlying diseases in cases of RPD are few and extremely variable, depending on the clinical setting. We examined the relative frequency of the underlying causes of RPD, in a university tertiary referral center, in Athens. A series of consecutive patients presenting with RPD in a 3-year period was included. All patients received a comprehensive clinical, imaging, and laboratory evaluation. Of a total of 279 patients hospitalized for dementia diagnosis, 68 patients had RPD (37 males and 31 females). Mean age at onset +/- SD was 65.5 +/- 10.0. The most common cause of RPD was secondary dementias, accounting for 18 cases (26.5%). Alzheimer disease and frontotemporal dementia were almost equally represented, accounting for 12 (17.6%) and 11 (16.2%) cases, respectively. Vascular dementia, Creutzfeldt-Jakob disease, and various neurodegenerative diseases accounted for 9 cases each (13.2%). In a tertiary referral center, secondary dementias represented the most frequent cause of cases presenting with RPD. As a substantial number of these cases are potentially treatable, our finding reconfirms and underscores the importance of an exhaustive evaluation in any case presenting with RPD.	en
heal.publisher	LIPPINCOTT WILLIAMS & WILKINS	en
heal.journalName	ALZHEIMER DISEASE & ASSOCIATED DISORDERS	en
dc.identifier.isi	ISI:000272403700007	en
dc.identifier.volume	23	en
dc.identifier.issue	4	en
dc.identifier.spage	337	en
dc.identifier.epage	346	en