Reevaluation of the Role of Duration of Morning Stiffness in the Assessment of Rheumatoid Arthritis Activity

Khan, NA; Yazici, Y; Calvo-Alen, J; Dadoniene, J; Gossec, L; Hansen, TM; Huisman, M; Kallikorm, R; Muller, R; Liveborn, M; Oding, R; Luchikhina, E; Naranjo, A; Rexhepl, S; Taylor, P; Tlustochowich, W; Tsirogianni, A; Sokka, T

dc.contributor.author	Khan, NA	en
dc.contributor.author	Yazici, Y	en
dc.contributor.author	Calvo-Alen, J	en
dc.contributor.author	Dadoniene, J	en
dc.contributor.author	Gossec, L	en
dc.contributor.author	Hansen, TM	en
dc.contributor.author	Huisman, M	en
dc.contributor.author	Kallikorm, R	en
dc.contributor.author	Muller, R	en
dc.contributor.author	Liveborn, M	en
dc.contributor.author	Oding, R	en
dc.contributor.author	Luchikhina, E	en
dc.contributor.author	Naranjo, A	en
dc.contributor.author	Rexhepl, S	en
dc.contributor.author	Taylor, P	en
dc.contributor.author	Tlustochowich, W	en
dc.contributor.author	Tsirogianni, A	en
dc.contributor.author	Sokka, T	en
dc.date.accessioned	2014-03-01T01:58:57Z
dc.date.available	2014-03-01T01:58:57Z
dc.date.issued	2009	en
dc.identifier.issn	0315-162X	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/28792
dc.subject	RHEUMATOID ARTHRITIS	en
dc.subject	SEVERITY OF ILLNESS INDEX	en
dc.subject	QUESTIONNAIRES	en
dc.subject	HEALTH STATUS INDICATORS	en
dc.subject	MORNING STIFFNESS	en
dc.subject.classification	Rheumatology	en
dc.subject.other	HEALTH-ASSESSMENT QUESTIONNAIRE	en
dc.subject.other	DISEASE-ACTIVITY INDEX	en
dc.subject.other	CLINICAL-TRIALS	en
dc.subject.other	ACTIVITY SCORE	en
dc.subject.other	CRITERIA	en
dc.subject.other	REMISSION	en
dc.subject.other	CARE	en
dc.subject.other	VALIDATION	en
dc.subject.other	MANAGEMENT	en
dc.subject.other	COUNTRIES	en
dc.title	Reevaluation of the Role of Duration of Morning Stiffness in the Assessment of Rheumatoid Arthritis Activity	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2009	en
heal.abstract	Objective. To evaluate file utility of the duration of morning stiffness (MS), as a patient-reported Outcome (PRO), in assessing rheumatoid arthritis (RA) disease activity. Methods. We acquired information oil 5439 patients in QUEST-RA, ail international database of patients with RA evaluated by a standard protocol. MS duration was assessed from time of waking to time of maximal improvement. Ability of MS duration to differentiate RA activity states. based on Disease Activity Score (DAS)28, was assessed by analysis of variance; and a receiver-operating, characteristic (ROC) Curve was plotted for discriminating clinically active (DAS28 > 3.2) from less active (DAS28 :5 3.2) RA. Mixed-effect analysis of covariance (ANCOVA) models were used to assess the utility of adding MS duration to Routine Assessment of Patient Index Data (RAPID)3, a PRO index based on physical function, pain, and general health (GH), in predicting the 3-variable DAS28 (DAS28v3). Results. MS duration had moderate correlation (r = 0.41-0.48) with pain, Health Assessment Questionnaire, and GH; and weak correlation (r = 0.23-0.39) with joint counts and erythrocyte sedimentation rate. MS duration differed significantly among patients with different RA activity (p < 0.001). The area under the ROC Curve of 0.74 (95% CI 0.72-0.75) showed moderate ability of MS duration to differentiate clinically active from less active RA. ANCOVA showed significant interactive effects between RAPID3 and the MS duration categories (p = 0.0005) in predicting DAS28v3. The effect of MS was found to be clinically important in patients with the low RAPID3 scores (< 6) in whom the presence of MS may indicate clinically active disease (DAS28v3 > 3.2). Conclusion. MS duration has a moderate correlation with RA disease activity. Assessment of MS duration may be clinically helpful ill patients with low RAPID3 scores. (First Release Oct 15 2009; J Rheumatol 2009;36:2435-42; doi: 10.3899/jrheum.081175)	en
heal.publisher	J RHEUMATOL PUBL CO	en
heal.journalName	JOURNAL OF RHEUMATOLOGY	en
dc.identifier.isi	ISI:000271593700011	en
dc.identifier.volume	36	en
dc.identifier.issue	11	en
dc.identifier.spage	2435	en
dc.identifier.epage	2442	en