Severe dopaminergic pathways damage in a case of chronic toluene abuse

Papageorgiou, SG; Karantoni, E; Pandis, D; Kouzoupis, AV; Kalfakis, N; Limouris, GS

dc.contributor.author	Papageorgiou, SG	en
dc.contributor.author	Karantoni, E	en
dc.contributor.author	Pandis, D	en
dc.contributor.author	Kouzoupis, AV	en
dc.contributor.author	Kalfakis, N	en
dc.contributor.author	Limouris, GS	en
dc.date.accessioned	2014-03-01T01:58:58Z
dc.date.available	2014-03-01T01:58:58Z
dc.date.issued	2009	en
dc.identifier.issn	0303-8467	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/28797
dc.subject	Toluene	en
dc.subject	Leukoencephalopathy	en
dc.subject	DaT-scan	en
dc.subject	Neuroleptic malignant syndrome	en
dc.subject	Dopamine	en
dc.subject.classification	Clinical Neurology	en
dc.subject.classification	Surgery	en
dc.subject.other	EXTRACELLULAR DOPAMINE	en
dc.subject.other	INHALATION	en
dc.subject.other	MICRODIALYSIS	en
dc.subject.other	PARKINSONISM	en
dc.subject.other	EXPOSURE	en
dc.subject.other	SYSTEM	en
dc.subject.other	RAT	en
dc.title	Severe dopaminergic pathways damage in a case of chronic toluene abuse	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2009	en
heal.abstract	Introduction: Toluene toxicity primarily affects central nervous system white matter, causing a characteristic brain MRI pattern. Case report: A toluene addicted man, after an abstinence period and a treatment with neuroleptics, presented with severe worsening of preexisting generalized tremor, opsoclonus, dysarthria, gait inability, jerky tendon reflexes and behaviour disorders. Magnetic resonance imaging showed mild leukoencephalopathy and hypointensities in deep gray matter nuclei. The DaT-scan revealed a decrease in presynaptic dopamine reuptake. Conclusion: Clinical and neuroradiological findings and the possible sensitivity to neuroleptics indicate dopaminergic impairment. Our case suggests that chronic toluene abuse causes presynaptic dopaminergic depletion. (C) 2009 Elsevier B.V. All rights reserved.	en
heal.publisher	ELSEVIER SCIENCE BV	en
heal.journalName	CLINICAL NEUROLOGY AND NEUROSURGERY	en
dc.identifier.isi	ISI:000272256800015	en
dc.identifier.volume	111	en
dc.identifier.issue	10	en
dc.identifier.spage	864	en
dc.identifier.epage	867	en