Aldosterone receptor blockade inhibits degenerative processes in the early stage of calcific aortic stenosis

Gkizas, S; Koumoundourou, D; Sirinian, X; Rokidi, S; Mavrilas, D; Koutsoukos, P; Papalois, A; Apostolakis, E; Alexopoulos, D; Papadaki, H

dc.contributor.author	Gkizas, S	en
dc.contributor.author	Koumoundourou, D	en
dc.contributor.author	Sirinian, X	en
dc.contributor.author	Rokidi, S	en
dc.contributor.author	Mavrilas, D	en
dc.contributor.author	Koutsoukos, P	en
dc.contributor.author	Papalois, A	en
dc.contributor.author	Apostolakis, E	en
dc.contributor.author	Alexopoulos, D	en
dc.contributor.author	Papadaki, H	en
dc.date.accessioned	2014-03-01T01:59:07Z
dc.date.available	2014-03-01T01:59:07Z
dc.date.issued	2010	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/28838
dc.subject	Angiotensin Converting Enzyme	en
dc.subject	Aortic Stenosis	en
dc.subject	Aortic Valve	en
dc.subject	Aortic Valve Disease	en
dc.subject	Blood Pressure	en
dc.subject	Immunohistochemistry	en
dc.subject	Potassium	en
dc.subject	Scanning Electron Microscopy	en
dc.subject	group 1	en
dc.subject	High Fat Diet	en
dc.subject	Mineralocorticoid Receptor	en
dc.subject	New Zealand	en
dc.title	Aldosterone receptor blockade inhibits degenerative processes in the early stage of calcific aortic stenosis	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.ejphar.2010.05.048	en
heal.identifier.secondary	http://dx.doi.org/10.1016/j.ejphar.2010.05.048	en
heal.publicationDate	2010	en
heal.abstract	Calcific aortic valve disease is associated with increased morbidity and mortality, especially in the elderly. To date, pharmacological therapies have not proven as effective as surgical intervention. Here, we used a hyperlipidemic rabbit model to investigate the potential effects of selective aldosterone inhibition on the early stages of aortic valve calcification, a pharmacological strategy that has not yet been tested.	en
heal.journalName	European Journal of Pharmacology	en
dc.identifier.doi	10.1016/j.ejphar.2010.05.048	en