Maximizing the benefits of screening mammography for women 40-49 years old

Bastardis-Zakas, K; Iatrakis, G; Navrozoglou, I; Peitsidis, P; Salakos, N; Malakassis, P; Zervoudis, S

dc.contributor.author	Bastardis-Zakas, K	en
dc.contributor.author	Iatrakis, G	en
dc.contributor.author	Navrozoglou, I	en
dc.contributor.author	Peitsidis, P	en
dc.contributor.author	Salakos, N	en
dc.contributor.author	Malakassis, P	en
dc.contributor.author	Zervoudis, S	en
dc.date.accessioned	2014-03-01T01:59:44Z
dc.date.available	2014-03-01T01:59:44Z
dc.date.issued	2010	en
dc.identifier.issn	03906663	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/29032
dc.relation.uri	http://www.scopus.com/inward/record.url?eid=2-s2.0-78650263212&partnerID=40&md5=9773c8b1c8d31cb033e7410254bc6c04	en
dc.subject	Mammography before 50 years old	en
dc.subject	Mammography in young women	en
dc.subject	Screening mammography	en
dc.subject.other	aging	en
dc.subject.other	article	en
dc.subject.other	breast cancer	en
dc.subject.other	cancer mortality	en
dc.subject.other	clinical trial	en
dc.subject.other	groups by age	en
dc.subject.other	human	en
dc.subject.other	mammography	en
dc.subject.other	meta analysis	en
dc.subject.other	mortality	en
dc.subject.other	screening	en
dc.subject.other	statistical significance	en
dc.subject.other	systematic review	en
dc.subject.other	Adult	en
dc.subject.other	Age Factors	en
dc.subject.other	Breast Neoplasms	en
dc.subject.other	Female	en
dc.subject.other	Humans	en
dc.subject.other	Mammography	en
dc.subject.other	Mass Screening	en
dc.subject.other	Meta-Analysis as Topic	en
dc.subject.other	Middle Aged	en
dc.subject.other	Randomized Controlled Trials as Topic	en
dc.subject.other	Risk	en
dc.title	Maximizing the benefits of screening mammography for women 40-49 years old	en
heal.type	journalArticle	en
heal.publicationDate	2010	en
heal.abstract	Background: While women aged 50 and older are broadly considered to benefit from screening mammograms, the evidence of any similar advantages for younger women are still considered insufficient to form any substantial conclusions on the matter. The primary goal of this study was to examine whether or not the mortality rate of younger women is benefited by mammography, and if so, how can this beneficial effect be maximized. Methods: The authors have taken into account all available randomized control trials (RCTs) and have conducted a meta-analysis based on those RCTs to study the effect of mammography on the mortality rate of women younger than age 50. Further interpretation on various aspects of the results has also led to separate meta-analyses, with the RCTs included grouped in accordance to the mean time interval between screening mammograms employed by each study. The findings and conclusions of the comparison were used to calculate the number of mammograms necessary to reduce the absolute death risk, depending on the time interval between screening mammograms. Results: The meta-analysis indicated a reduction in breast-cancer mortality in the intervention group, which reached statistical significance (relative risk (RR) 0.81 [95% CI 0.71-0.93] p < 0.01). Furthermore, when the RCTs included were grouped according to their mean time interval between mammograms, there was a definite increase of statistical significance in favor of those RCTs with shorter interval times (RR 0.76 [95% CI 0.64-0.89] p < 0.01). Conclusions: The significant mortality rate reduction demonstrated by the meta-analytical results is a key indicator of the beneficial effect of mammography on the age group of women younger than 50. Additionally, the increase in the aforesaid significance when combining RCTs with short time intervals between mammograms, as opposed to those RCTs with longer intervals, suggests that the optimal use of mammographic screening lies with the former. This is better demonstrated when taking in account our approach to answering the practical question of ""how many screening mammograms will take to save one life?"" in correlation with the mean time interval involved.	en
heal.journalName	Clinical and Experimental Obstetrics and Gynecology	en
dc.identifier.volume	37	en
dc.identifier.issue	4	en
dc.identifier.spage	278	en
dc.identifier.epage	282	en