The effect of local use of nandrolone decanoate on rotator cuff repair in rabbits

Papaspiliopoulos, A; Papaparaskeva, K; Papadopoulou, E; Feroussis, J; Papalois, A; Zoubos, A

dc.contributor.author	Papaspiliopoulos, A	en
dc.contributor.author	Papaparaskeva, K	en
dc.contributor.author	Papadopoulou, E	en
dc.contributor.author	Feroussis, J	en
dc.contributor.author	Papalois, A	en
dc.contributor.author	Zoubos, A	en
dc.date.accessioned	2014-03-01T02:00:00Z
dc.date.available	2014-03-01T02:00:00Z
dc.date.issued	2010	en
dc.identifier.issn	08941939	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/29064
dc.subject	Anabolic steroids	en
dc.subject	Drug abuse	en
dc.subject	Nandrolone decanoate	en
dc.subject	Rotator cuff repair	en
dc.subject	Tendon healing	en
dc.subject	Tendon injury	en
dc.subject.other	nandrolone decanoate	en
dc.subject.other	animal experiment	en
dc.subject.other	animal model	en
dc.subject.other	article	en
dc.subject.other	biomechanics	en
dc.subject.other	controlled study	en
dc.subject.other	fibroblast	en
dc.subject.other	healing	en
dc.subject.other	histopathology	en
dc.subject.other	immobilization	en
dc.subject.other	inflammation	en
dc.subject.other	male	en
dc.subject.other	nonhuman	en
dc.subject.other	priority journal	en
dc.subject.other	rabbit	en
dc.subject.other	rotator cuff injury	en
dc.subject.other	tendon reconstruction	en
dc.subject.other	Anabolic Agents	en
dc.subject.other	Animals	en
dc.subject.other	Biomechanics	en
dc.subject.other	Male	en
dc.subject.other	Models, Animal	en
dc.subject.other	Nandrolone	en
dc.subject.other	Rabbits	en
dc.subject.other	Recovery of Function	en
dc.subject.other	Restraint, Physical	en
dc.subject.other	Rotator Cuff	en
dc.subject.other	Tendons	en
dc.subject.other	Wound Healing	en
dc.title	The effect of local use of nandrolone decanoate on rotator cuff repair in rabbits	en
heal.type	journalArticle	en
heal.identifier.primary	10.3109/08941939.2010.481007	en
heal.identifier.secondary	http://dx.doi.org/10.3109/08941939.2010.481007	en
heal.publicationDate	2010	en
heal.abstract	Objective: There is still controversy about the effect of anabolic steroid on connective tissue. This study examines the hypothesis that the local use of nandrolone decanoate, an anabolic steroid on rotator cuff, facilitates the healing process when used in combination with surgical repair. Methods: Forty-eight male rabbits were divided in four groups with anabolic steroids (Nandrolone Decanoate 10 mg/kg) and immobilization as variables. The groups were the following: first group, nonsteroid use-immobilization (NSI); second group, nonsteroid use-nonimmobilization (NSNI); third group, steroid use-immobilization (SI); fourth group steroid use-nonimmobilization (SNI). Every rabbit underwent a rotator cuff incision and reconstruction. Fifteen days later the tendons were sent for biomechanical and histological evaluation. Results: Groups that did not receive anabolic steroids showed better healing and more tendon strength in comparison to groups that received anabolic steroids. Microscopic examination of specimens from the groups without the use of anabolic steroid showed extensive fibroblastic activity whereas the specimens from those groups with anabolic steroid use showed focal fibroblastic reaction and inflammation. Immobilization provided better results in the groups with anabolic steroid use but it did not influence healing in groups without steroids. Conclusions: The effect of local nandrolone decanoate use on a rotator cuff tear is detrimental, acting as a healing inhibitor. © 2010 Informa Healthcare USA, Inc.	en
heal.journalName	Journal of Investigative Surgery	en
dc.identifier.doi	10.3109/08941939.2010.481007	en
dc.identifier.volume	23	en
dc.identifier.issue	4	en
dc.identifier.spage	204	en
dc.identifier.epage	207	en