Design and Synthesis of Optically Active Esters of gamma-Amino-beta-oxo Acids as Precursors for the Synthesis of Tetramic Acids Derived from L-Serine, L-Tyrosine, and L-Threonine

Matiadis, D; Igglessi-Markopoulou, O

dc.contributor.author	Matiadis, D	en
dc.contributor.author	Igglessi-Markopoulou, O	en
dc.date.accessioned	2014-03-01T02:00:20Z
dc.date.available	2014-03-01T02:00:20Z
dc.date.issued	2010	en
dc.identifier.issn	1434-193X	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/29085
dc.subject	Cyclization	en
dc.subject	Nitrogen heterocycles	en
dc.subject	Acylation	en
dc.subject	Amino acids	en
dc.subject.classification	Chemistry, Organic	en
dc.subject.other	MYXOMYCETE PHYSARUM-MELLEUM	en
dc.subject.other	SOLID-PHASE SYNTHESIS	en
dc.subject.other	ANTINEOPLASTIC AGENTS	en
dc.subject.other	3-ACYLTETRAMIC ACIDS	en
dc.subject.other	N-HYDROXYSUCCINIMIDE	en
dc.subject.other	DERIVATIVES	en
dc.subject.other	EQUISETIN	en
dc.subject.other	ANALOGS	en
dc.title	Design and Synthesis of Optically Active Esters of gamma-Amino-beta-oxo Acids as Precursors for the Synthesis of Tetramic Acids Derived from L-Serine, L-Tyrosine, and L-Threonine	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2010	en
heal.abstract	Tetramic acids bearing a hydroxyalkyl or hydroxybenzyl group at C-5 of the heterocyclic ring were successfully prepared. alpha-Amino acids appropriately protected and activated were used as acylating agents for the C-acylation of active methylene compounds. These novel synthesized intermediates, substituted gamma-amino acids, were isolated in excellent yields and enantiomeric purities. Cyclization under basic conditions afforded the desired products in high yields and enantiomeric purity.	en
heal.publisher	WILEY-V C H VERLAG GMBH	en
heal.journalName	EUROPEAN JOURNAL OF ORGANIC CHEMISTRY	en
dc.identifier.isi	ISI:000284515800008	en
dc.identifier.issue	31	en
dc.identifier.spage	5989	en
dc.identifier.epage	5995	en